ArticleBMC infectious diseases2020
Altered respiratory microbiota composition and functionality associated with asthma early in life.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The alterations of airway and intestine microbiota in asthma: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Functional and Resistome Profiling of Paediatric Airway Microbiota in Asthma Using Shotgun Metagenomics.Biomedicines · 2026Article
- Article
- The airway mycobiome in chronic respiratory diseases: current advances and future frontiers.Journal of translational medicine · 2025Review
- Advances in the Gut-Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential.Clinical and translational allergy · 2025Review
- Respiratory Microbiota Associations with Asthma Across American and Emirati Adults: A Comparative Analysis.Applied microbiology (Basel, Switzerland) · 2025Article
- Associations Between Indoor Fungal Community Structures and Environmental Factors: Insights from the Evidence-Driven Indoor Air-Quality Improvement Study.Journal of fungi (Basel, Switzerland) · 2025Article
- From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences.Molecular neurobiology · 2025Review
- Nebulization of 2% lidocaine has no detectable impact on the healthy equine respiratory microbiota.PloS one · 2025Article
- The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review.Environmental health perspectives · 2024Review
- Evaluation of clinical characteristics and risk factors associated with Chlamydia psittaci infection based on metagenomic next-generation sequencing.BMC microbiology · 2024Article
- Lung microbiota: implications and interactions in chronic pulmonary diseases.Frontiers in cellular and infection microbiology · 2024Review
- Functional alterations and predictive capacity of gut microbiome in type 2 diabetes.Scientific reports · 2023Article
- Paediatric Asthma and the Microbiome: A Systematic Review.Microorganisms · 2023Review
- The oral bacteriomes of patients with allergic rhinitis and asthma differ from that of healthy controls.Frontiers in microbiology · 2023Article
- Upper respiratory tract mycobiome alterations in different kinds of pulmonary disease.Frontiers in microbiology · 2023Article
- Characterization of the Microbiome and Host's Metabolites of the Lower Respiratory Tract During Acute Community-Acquired Pneumonia Identifies Potential Novel Markers.Infection and drug resistance · 2023Article
- Dysbiotic lung microbial communities of neonates from allergic mothers confer neonate responsiveness to suboptimal allergen.Frontiers in allergy · 2023Article
- Article
- Altered Composition of the Oral Microbiota in Depression Among Cigarette Smokers: A Pilot Study.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundThe microbiota of the respiratory tract has an important role in maintaining respiratory health. However, little is known on the respiratory microbiota in asthmatic patients among Middle Eastern populations. This study investigated the respiratory microbiota composition and functionality associated with asthma in Emirati subjects.
methodsWe performed 16S rRNA and ITS2-gene based microbial profiling of 40 expectorated sputum samples from adult and pediatric Emirati individuals averaging 52 and 7 years of age, respectively with or without asthma.
resultsWe report bacterial difference belonging to Bacteroidetes, Firmicutes, Fusobacteria and Proteobacteria phyla between asthmatic and non-asthmatic controls. Similarly, fungal difference belonging to Ascomycota, Basidiomycota phyla and other unclassified fungi. Differential abundance testing among asthmatic individuals with relation to Asthma Control Test show a significant depletion of Penicillium aethiopicum and Alternaria spp., among poorly controlled asthmatics. Moreover, data suggest a significant expansion of Malassezia spp. and other unclassified fungi in the airways of those receiving steroids and leukotriene receptor antagonists' combination therapy, in contrast to those receiving steroids alone. Functional profiling from 16S data showed marked differences between pediatric asthmatic and non-asthmatic controls, with pediatric asthmatic patients showing an increase in amino acid (p-value < 5.03 × 10
conclusionsThese differences provide an insight into respiratory microbiota composition in Emirati population and its possible role in the development of asthma early in life. This study provides important information that may eventually lead to the development of screening biomarkers to predict early asthma development and novel therapeutic approaches.
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