SynthesisEmerging microbes & infections2020
Meta-analysis of diagnostic performance of serology tests for COVID-19: impact of assay design and post-symptom-onset intervals.
Synthesis in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A systematic and meta-analysis review on the diagnostic accuracy of antibodies in the serological diagnosis of COVID-19.Systematic reviews · 2021Pooled it
- Robotic pancreaticoduodenectomy in patients with overweight or obesity: a meta-analysis protocol.BMJ open · 2024Article
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- Article
- Diagnostic performance of four lateral flow immunoassays for COVID-19 antibodies in Peruvian population.PLOS global public health · 2023Article
- PCR combined with serologic testing improves the yield and efficiency of SARS-CoV-2 infection hunting: A study in 40,689 consecutive overseas arrivals.Frontiers in public health · 2023Article
- An update on lateral flow immunoassay for the rapid detection of SARS-CoV-2 antibodies.AIMS microbiology · 2023Review
- Sensitivity of three commercial tests for SARS-CoV-2 serology in children: an Italian multicentre prospective study.Italian journal of pediatrics · 2022Article
- Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and future.Emerging microbes & infections · 2022Article
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulins using chemiluminescence immunoassay and its correlation with neutralizing antibodies.Virus research · 2022Article
- The influence of time on the sensitivity of SARS-CoV-2 serological testing.Scientific reports · 2022Article
- Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study.Journal of translational medicine · 2022Article
- The Comparability of Anti-Spike SARS-CoV-2 Antibody Tests is Time-Dependent: a Prospective Observational Study.Microbiology spectrum · 2022Observational
- The Influence of Time on the Sensitivity of SARS-CoV-2 Serological Testing.Research square · 2022Article
- Comparison of six antibody assays and two combination assays for COVID-19.Virology journal · 2022Article
- Usefulness of rapid antigen testing for SARS-CoV-2 screening of healthcare workers: a pilot study.Clinical and experimental medicine · 2022Article
- The Trend of IgG and IgM Antibodies During 6-Month Period After the Disease Episode in COVID-19 Patients.Iranian journal of science and technology. Transaction A, Science · 2022Article
- A systematic review and meta-analysis of the sensitivity of antibody tests for the laboratory confirmation of COVID-19.Future virology · 2021Review
- Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Review
- Evaluation of Three Commercial and Two Non-Commercial Immunoassays for the Detection of Prior Infection to SARS-CoV-2.The journal of applied laboratory medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serology detection is recognized for its sensitivity in convalescent patients with COVID-19, in comparison with nucleic acid amplification tests (NAATs). This article aimed to evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals. Two authors independently searched PubMed, Cochrane library, Ovid, EBSCO for case-control, longitudinal and cohort studies that determined the diagnostic accuracy of serology tests in comparison with NAATs in COVID-19 cases and used QUADAS-2 for quality assessment. Pooled accuracy was analysed using INLA method. A total of 27 studies were included in this meta-analysis, with 4 cohort, 16 case-control and 7 longitudinal studies and 4565 participants. Serology tests had the lowest sensitivity at 0-7 days after symptom onset and the highest at >14 days. TAB had a better sensitivity than IgG or IgM only. Using combined nucleocapsid (N) and spike(S) protein had a better sensitivity compared to N or S protein only. Lateral flow immunoassay (LFIA) had a lower sensitivity than enzyme-linked immunoassay (ELISA) and chemiluminescent immunoassay (CLIA). Serology tests will play an important role in the clinical diagnosis for later stage COVID-19 patients. ELISA tests, detecting TAB or targeting combined N and S proteins had a higher diagnostic sensitivity compared to other methods.
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