Evidence map›Paper›PMID 32962518›Full record

ArticleCirculation research2020

Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.

David S Park, Akshay Shekhar, John Santucci, Gabriel Redel-Traub, Sergio Solinas, Shana Mintz, Xianming Lin, Ernest Whanwook Chang, Deven Narke, Yuhe Xia and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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  9. The Interaction Between NaCirculation research · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

David S Park *The Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Akshay Shekhar *The Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
John SantucciThe Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Gabriel Redel-TraubThe Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Sergio SolinasUniversity of Zurich, Institute of Neuroinformatics, Switzerland (S.S.).
Shana MintzThe Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Xianming LinThe Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Ernest Whanwook ChangThe Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Deven NarkeThe Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Yuhe XiaDepartment of Population Health (Y.X.), New York University School of Medicine.
Mitchell GoldfarbHunter College of City University, Department of Biological Sciences, New York (S.S., M.G.).
Glenn I FishmanThe Leon H. Charney Division of Cardiology (D.S.P., A.S., J.S., G.R.-T., S.M., X.L., E.W.C., D.N., G.I.F.), New York University School of Medicine.
Norwegian Womens Public Health Association · NOHunter College · USNew York University · USRegeneron (United States) · USSIB Swiss Institute of Bioinformatics · CHSt. John's University · USUnited States Nuclear Regulatory Commission · US

Funding

Training Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9M
FHFs and Cardiac ElectrophysiologyR01HL142498 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHMAN, GLENN I · 2018 to 2021
$3.2M
Training in Pharmacological SciencesT32GM066704 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2004 to 2018
$2.6M
NRG-1 dependent transcriptional networks that dictate Purkinje cell fate decisionsF31HL132438 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHEKHAR, AKSHAY · 2016 to 2017
$68k
NHLBI NIH HHS F31 HL132438NHLBI NIH HHS R01 HL142498NHLBI NIH HHS T32 HL098129NIGMS NIH HHS T32 GM066704
6 · The paper itself

Abstract

rationaleFHFs (fibroblast growth factor homologous factors) are key regulators of sodium channel (Na

objectiveUsing animal models and theoretical multicellular linear strands, we examined how FHF2 orchestrates the interdependency of sodium, calcium, and gap junctional conductances to safeguard cardiac conduction. METHODS AND

results

conclusionsFHF2-dependent effects on Na

Indexed as

Action PotentialsHeart RateAnimalsArrhythmias, CardiacCalcium SignalingComputer SimulationConnexin 43Disease Models, AnimalFibroblast Growth FactorsGap JunctionsGenetic Predisposition to DiseaseMaleMice, 129 StrainMice, KnockoutModels, CardiovascularMyocytes, CardiacConnexin 43fibroblast growth factor 13Fibroblast Growth FactorsGJA1 protein, mouseSodiumSodium Channelsaction potentialBrugada syndromefibroblast growth factorgap junctionsodium channel

Identifiers

PMID32962518
PMCPMC7718431
OpenAlexW3088175064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.