Evidence map›Paper›PMID 32962427›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.

Michael Kugler, Josef Holub, Jiří Brynda, Klára Pospíšilová, Suzan El Anwar, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, Milan Fábry, Bohumír Grüner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Michael KuglerDeparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-0752-9682
Josef HolubDepartment of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Jiří BryndaDeparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID https://orcid.org/0000-0003-3675-6769
Klára PospíšilováDeparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Suzan El AnwarDepartment of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Dmytro BavolDepartment of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Miroslav HavránekChemistry Department, Apigenex, s.r.o., Prague, Czech Republic.
Vlastimil KrálDeparment of Structural Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Milan FábryDeparment of Structural Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Bohumír GrünerDepartment of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.ORCID https://orcid.org/0000-0002-2595-9125
Pavlína ŘezáčováDeparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID https://orcid.org/0000-0001-9626-346X
Czech Academy of Sciences, Institute of Molecular Genetics · CZCzech Academy of Sciences, Institute of Inorganic Chemistry · CZApigenex (Czechia) · CZCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics. We recently identified sulfonamide dicarbaboranes as promising inhibitors of CA IX with favourable activities both

Indexed as

Amino Acid SequenceAntigens, NeoplasmAntineoplastic AgentsBoron CompoundsCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCatalytic DomainCrystallography, X-RayDrug Screening Assays, AntitumorHEK293 CellsHumansHydrophobic and Hydrophilic InteractionsProtein BindingStructure-Activity RelationshipSulfonamidesAntigens, NeoplasmAntineoplastic AgentsBoron CompoundsCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXdecaboraneSulfonamidesCarbonic anhydrase IXcarboraneenzyme inhibitorsstructure-activity relationship

Identifiers

PMID32962427
PMCPMC7534198
OpenAlexW3088840269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.