Evidence map›Paper›PMID 32962100›Full record

ReviewNutrients2020

Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases.

Sarah G Francisco, Kelsey M Smith, Gemma Aragonès, Elizabeth A Whitcomb, Jasper Weinberg, Xuedi Wang, Eloy Bejarano, Allen Taylor, Sheldon Rowan

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. The Association of Dietary Patterns with Age-Related Macular Degeneration in a Multiethnic Older Singaporean Population.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Glycative stress as a cause of macular degeneration.Progress in retinal and eye research · 2024
    Review
  16. Observational
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sarah G FranciscoJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Kelsey M SmithJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Gemma AragonèsJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-1924-9231
Elizabeth A WhitcombJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Jasper WeinbergJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Xuedi WangJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Eloy BejaranoJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Allen TaylorJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-2581-1825
Sheldon RowanJM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-1123-6743
Tufts University · US

Funding

Mechanistically linking AMD, glycemic index and protein homeostasisR01EY028559 · NEI · TUFTS UNIVERSITY BOSTON · PI TAYLOR, ALLEN · 2018 to 2022
$1.5M
Ubiquitin function in eye lensR01EY026979 · NEI · TUFTS UNIVERSITY BOSTON · PI TAYLOR, ALLEN · 2016 to 2018
$1.2M
Research Training Program in Nutrition, Obesity and Metabolic DisordersT32DK124170 · NIDDK · TUFTS UNIVERSITY BOSTON · PI GREENBERG, ANDREW S · 2020 to 2024
$870k
Agricultural Research Service 8050-51000-089-01SBrightFocus Foundation M2017147Edward N. and Della L. Thome Memorial Foundation AMD awardHNRCA PilotKamada grantNational Institute of Food and Agriculture 2016-08885NEI NIH HHS RO1EY026979NEI NIH HHS RO1EY028559NIDDK NIH HHS T32 DK124170
6 · The paper itself

Abstract

Over a third of older adults in the U.S. experience significant vision loss, which decreases independence and is a biomarker of decreased health span. As the global aging population is expanding, it is imperative to uncover strategies to increase health span and reduce the economic burden of this age-related disease. While there are some treatments available for age-related vision loss, such as surgical removal of cataracts, many causes of vision loss, such as dry age-related macular degeneration (AMD), remain poorly understood and no treatments are currently available. Therefore, it is necessary to better understand the factors that contribute to disease progression for age-related vision loss and to uncover methods for disease prevention. One such factor is the effect of diet on ocular diseases. There are many reviews regarding micronutrients and their effect on eye health. Here, we discuss the impact of dietary patterns on the incidence and progression of age-related eye diseases, namely AMD, cataracts, diabetic retinopathy, and glaucoma. Then, we focus on the specific role of dietary carbohydrates, first by outlining the physiological effects of carbohydrates on the body and then how these changes translate into eye and age-related ocular diseases. Finally, we discuss future directions of nutrition research as it relates to aging and vision loss, with a discussion of caloric restriction, intermittent fasting, drug interventions, and emerging randomized clinical trials. This is a rich field with the capacity to improve life quality for millions of people so they may live with clear vision for longer and avoid the high cost of vision-saving surgeries.

Indexed as

DietDietary CarbohydratesFeeding BehaviorHumansMacular DegenerationRisk FactorsDietary Carbohydratesage-related macular degenerationcaloric restrictioncataractdiabetic retinopathydietary patternglaucomaglycemic indexintermittent fastingMediterranean diet

Identifiers

PMID32962100
PMCPMC7551870
OpenAlexW3087165374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.