Evidence map›Paper›PMID 32962082›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Antigen-Specific Cytokine and Chemokine Gene Expression for Diagnosing Latent and Active Tuberculosis.

Workneh Korma, Adane Mihret, Yunhee Chang, Azeb Tarekegn, Metasebiya Tegegn, Adem Tuha, Dasom Hwang, Mesfin Asefa, Mahlet O Hasen, Seoyoung Kim and 2 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Recent Advances in Diagnosis and Management of Female Genital Tuberculosis.Journal of obstetrics and gynaecology of India · 2021
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Workneh KormaMolecular Diagnostic Laboratory, Department of Biomedical Laboratory Sciences, Yonsei University, Wonju 26493, Korea.ORCID 0000-0002-5011-4984
Adane MihretArmauer Hansen Research Institute, Addis Ababa, P.O Box 1005, Ethiopia.ORCID 0000-0003-3183-4772
Yunhee ChangMolecular Diagnostic Laboratory, Department of Biomedical Laboratory Sciences, Yonsei University, Wonju 26493, Korea.
Azeb TarekegnArmauer Hansen Research Institute, Addis Ababa, P.O Box 1005, Ethiopia.
Metasebiya TegegnArmauer Hansen Research Institute, Addis Ababa, P.O Box 1005, Ethiopia.
Adem TuhaArmauer Hansen Research Institute, Addis Ababa, P.O Box 1005, Ethiopia.
Dasom HwangMolecular Diagnostic Laboratory, Department of Biomedical Laboratory Sciences, Yonsei University, Wonju 26493, Korea.
Mesfin AsefaSt. Paul's Hospital Millennium Medical College, Department of pathology, Addis Ababa, P.O. Box 1271, Ethiopia.
Mahlet O HasenArmauer Hansen Research Institute, Addis Ababa, P.O Box 1005, Ethiopia.
Seoyoung KimMolecular Diagnostic Laboratory, Department of Biomedical Laboratory Sciences, Yonsei University, Wonju 26493, Korea.
Tesfaye S TesemaInstitute of Biotechnology, Addis Ababa University, Addis Ababa, P.O. Box 1176, Ethiopia.ORCID 0000-0002-4103-5029
Hyeyoung LeeMolecular Diagnostic Laboratory, Department of Biomedical Laboratory Sciences, Yonsei University, Wonju 26493, Korea.
Armauer Hansen Research Institute · ETYonsei University · KRAddis Ababa University · ETSt. Paul's Hospital Millennium Medical College · ET

Funding

Ethiopia-Emory TB Research Training ProgramD43TW009127 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Kidist Bobosha · 2013 to 2026
$3.4M
FIC NIH HHS D43 TW009127National Research Foundation of Korea NFR-2017K2A9A1A01092944
6 · The paper itself

Abstract

Tuberculosis infection exhibits different forms, namely, pulmonary, extrapulmonary, and latent. Here, diagnostic markers based on the gene expression of cytokines and chemokines for differentiating between tuberculosis infection state(s) were identified. Gene expression of seven cytokines (Interferon gamma (IFN-γ), Interferon gamma-induced protein 10 (IP-10), Interleukin-2 receptor (IL-2R), C-X-C Motif Chemokine Ligand 9 (CXCL-9), Interleukin 10 (IL-10), Interleukin 4 (IL-4), and Tumor Necrosis Factor alpha (TNF-α)) in response to tuberculosis antigen was analyzed using real-time polymerase reaction. The sensitivity and specificity of relative quantification (2^

Indexed as

chemokinescytokine and chemokine biomarkercytokinesdiagnosticsextrapulmonary tuberculosisgene expressionRT-PCRtuberculosis biomarkerTuberculosis diagnosis

Identifiers

PMID32962082
PMCPMC7555064
OpenAlexW3087363366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.