Evidence map›Paper›PMID 32962062›Full record

ArticleGenes2020

RETRACTED: The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures.

Paulina Wigner, Ewelina Synowiec, Paweł Jóźwiak, Piotr Czarny, Katarzyna Białek, Michal Bijak, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Sliwinski

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Paulina WignerLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Ewelina SynowiecLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Paweł JóźwiakDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Piotr CzarnyDepartment of Medical Biochemistry, Medical University of Lodz, 92-216 Lodz, Poland.
Katarzyna BiałekLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.
Michal BijakBiohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.ORCID 0000-0002-7838-4097
Janusz SzemrajDepartment of Medical Biochemistry, Medical University of Lodz, 92-216 Lodz, Poland.
Piotr GrucaInstitute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.ORCID 0000-0001-5709-0359
Mariusz PappInstitute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Tomasz SliwinskiLaboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.ORCID 0000-0001-8385-7744
University of Łódź · PLMaj Institute of Pharmacology · PLMedical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is the serious mental disorder. Previous studies suggest that the development mechanism of depression may be associated with disorders of the tryptophan catabolic pathway (TRYCAT). Thus, this study investigates the effect of agomelatine treatment on the expression and methylation status of genes involved in TRYCAT in the brain and blood of rats exposed to a chronic mild stress (CMS). Separate groups of rats were exposed to CMS for two or seven weeks; the second group received vehicle or agomelatine for five weeks. After completion of both stress conditions and treatment, the expression levels of messenger RNA (mRNA) and protein, as well as the methylation status of promoters, were measured in peripheral blood mononuclear cells (PBMCs) and in brain structures with the use of TaqMan Gene Expression Assay, Western blot, and methylation-sensitive high-resolution melting techniques. In PBMCs,

Indexed as

DNA MethylationAcetamidesAcetyltransferasesAnimalsBrainChronic DiseaseGene Expression RegulationHypnotics and SedativesIndoleamine-Pyrrole 2,3,-DioxygenaseLeukocytes, MononuclearMaleNaphthalenesRatsRats, WistarStress, PsychologicalTryptophanAcetamidesAcetyltransferasesagomelatineHypnotics and SedativesIdo1 protein, ratIndoleamine-Pyrrole 2,3,-Dioxygenasekinamycin acetyltransferase INaphthalenestph1 protein, rattph2 protein, ratTryptophanTryptophan Hydroxylaseagomelatinechronic mild stressdepressiongene expression and methylationtryptophan catabolic pathway

Identifiers

PMID32962062
PMCPMC7563711
OpenAlexW3087253673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.