ArticleInternational journal of environmental research and public health2020
The Role of Iron Metabolism in Fatigue, Depression, and Quality of Life in Multiple Sclerosis Patients.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Micronutrient-immune interactions in mood and psychotic disorders: a case-control study of vitamin C, iron, zinc, magnesium, and peripheral blood cell indices.Scientific reports · 2026Article
- Targeting ferroptosis as a novel strategy for depressive mental disorders.Psychopharmacology · 2026Review
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
- Review
- Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway.Drug design, development and therapy · 2025Article
- Circulatory Indicators of Lipid Peroxidation, the Driver of Ferroptosis, Reflect Differences between Relapsing-Remitting and Progressive Multiple Sclerosis.International journal of molecular sciences · 2024Article
- Association of multiple sclerosis with stroke: A comprehensive review.Health science reports · 2024Article
- Ferroptosis: a new antidepressant pharmacological mechanism.Frontiers in pharmacology · 2023Review
- Chronic Fatigue Syndrome in Patients with Deteriorated Iron Metabolism.Diagnostics (Basel, Switzerland) · 2022Review
- Iron deficiency is related to low functional outcome in patients at early rehabilitation after acute stroke.Journal of cachexia, sarcopenia and muscle · 2022Observational
- Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder.Frontiers in psychiatry · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a chronic inflammatory disease of autoimmune origin for which there is currently no available cure. In the course of MS, next to neurological disorders, patients often present with chronic fatigue syndrome and depressive disorders, which impact on their daily function and quality of life. The aim of study was to analyse the relationship between serum parameters of iron metabolism and the severity of fatigue, depressive symptoms, and quality of life in MS patients.
methodsThe study sample consisted of 90 people with a diagnosis of multiple sclerosis, age range 19-67 years, whose functional status evaluated using the Expanded Disability Status Scale in 90% of the participants did not exceed 3.5 points. Venous blood samples were collected for blood cell count determination and for the purposes of obtaining serum analysed for the concentrations of iron, ferritin, transferrin, transferrin saturation, unsaturated iron binding capacity (UIBC), and total iron binding capacity (TIBC). The participants were also evaluated according to the Fatigue Severity Scale, Beck Depression Inventory, and Functional Assessment of Multiple Sclerosis.
resultsFerritin levels were significantly correlated with the severity of depressive symptoms (r = -0.22;
conclusionsFerritin deficiency in MS patients is associated with an exacerbation of depressive disorders and a decline in quality of life. Symptoms of fatigue in MS patients are inversely proportional to mood and quality of life.
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