Evidence map›Paper›PMID 32961842›Full record

ArticleInternational journal of molecular sciences2020

1,4-Disubstituted-1,2,3-Triazole Compounds Induce Ultrastructural Alterations in

Fernando Almeida-Souza, Verônica Diniz da Silva, Gabriel Xavier Silva, Noemi Nosomi Taniwaki, Daiana de Jesus Hardoim, Camilla Djenne Buarque, Ana Lucia Abreu-Silva, Kátia da Silva Calabrese

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

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  11. Antibiotics (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Fernando Almeida-SouzaPós-graduação em Ciência Animal, Universidade Estadual do Maranhão, São Luís 65055-310, Brazil.ORCID 0000-0003-0047-6159
Verônica Diniz da SilvaLaboratório de Síntese Orgânica, Pontifícia Universidade Católica, Rio de Janeiro 22451-900, Brazil.
Gabriel Xavier SilvaRede Nordeste de Biotecnologia, Universidade Federal do Maranhão, São Luís 65080-805, Brazil.
Noemi Nosomi TaniwakiNúcleo de Microscopia Eletrônica, Instituto Adolfo Lutz, São Paulo 01246-000, Brazil.
Daiana de Jesus HardoimLaboratório de Imunomodulação e Protozoologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.
Camilla Djenne BuarqueLaboratório de Síntese Orgânica, Pontifícia Universidade Católica, Rio de Janeiro 22451-900, Brazil.
Ana Lucia Abreu-SilvaPós-graduação em Ciência Animal, Universidade Estadual do Maranhão, São Luís 65055-310, Brazil.ORCID 0000-0003-2167-3725
Kátia da Silva CalabreseLaboratório de Imunomodulação e Protozoologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.
Fundação Oswaldo Cruz · BRPontifícia Universidade Católica do Rio de Janeiro · BRUniversidade Estadual do Maranhão · BRInstituto Adolfo Lutz · BRUniversidade Federal do Maranhão · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309885/2017-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.363006/2019-00Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.001759/2019
6 · The paper itself

Abstract

The current standard treatment for leishmaniasis has remained the same for over 100 years, despite inducing several adverse effects and increasing cases of resistance. In this study we evaluated the in vitro antileishmanial activity of 1,4-disubstituted-1,2,3 triazole compounds and carried out in silico predictive study of their pharmacokinetic and toxicity properties. Ten compounds were analyzed, with compound

Indexed as

AnimalsCells, CulturedComputer SimulationFemaleInhibitory Concentration 50Leishmania mexicanaLeishmaniasis, CutaneousMacrophages, PeritonealMiceMice, Inbred BALB CMicroscopy, Electron, TransmissionMitochondriaNitritesTriazolesNitritesTriazolesADMEcytotoxicityleishmaniasistoxicitytransmission electron microscopytreatment

Identifiers

PMID32961842
PMCPMC7555349
OpenAlexW3085018661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.