Evidence map›Paper›PMID 32961824›Full record

ArticleMolecules (Basel, Switzerland)2020

Adenosine Receptor Ligands: Coumarin-Chalcone Hybrids as Modulating Agents on the Activity of

Saleta Vazquez-Rodriguez, Santiago Vilar, Sonja Kachler, Karl-Norbert Klotz, Eugenio Uriarte, Fernanda Borges, Maria João Matos

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Multi-target Phenylpropanoids Against Epilepsy.Current neuropharmacology · 2024
    Review
  3. Review
  4. Review
  5. Coumarin and Its Derivatives-Editorial.Molecules (Basel, Switzerland) · 2021
    Article
  6. Trending Topics on Coumarin and Its Derivatives in 2020.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Saleta Vazquez-RodriguezDepartamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Santiago VilarDepartamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Sonja KachlerInstitut für Pharmakologie und Toxikologie, Universität Würzburg, 97078 Würzburg, Germany.
Karl-Norbert KlotzInstitut für Pharmakologie und Toxikologie, Universität Würzburg, 97078 Würzburg, Germany.
Eugenio UriarteDepartamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Fernanda BorgesCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua Campo Alegre 687, 4169-007 Porto, Portugal.
Maria João MatosDepartamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Universidade de Santiago de Compostela · ESUniversidade do Porto · PTUniversity of Würzburg · DE

Funding

Fundação para a Ciência e Tecnologia CEECIND/02423/2018Xunta de Galicia ED481B 2014/027-0, ED481B 2014/086-0 and ED481B 2018/007
6 · The paper itself

Abstract

Adenosine receptors (ARs) play an important role in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, epilepsy and schizophrenia. The different subtypes of ARs and the knowledge on their densities and status are important for understanding the mechanisms underlying the pathogenesis of diseases and for developing new therapeutics. Looking for new scaffolds for selective AR ligands, coumarin-chalcone hybrids were synthesized (compounds

Indexed as

Binding SitesChalconeChalconesDrug DesignHumansKineticsLigandsMolecular Docking SimulationProtein BindingReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A3Structure-Activity RelationshipChalconeChalconesLigandsReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A3adenosine receptorsbinding affinitychalconecoumarindockingneurodegenerative diseases

Identifiers

PMID32961824
PMCPMC7571217
OpenAlexW3087137638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.