Evidence map›Paper›PMID 32961709›Full record

ArticleMolecules (Basel, Switzerland)2020

Impact of Cholesterol on the Stability of Monomeric and Dimeric Forms of the Translocator Protein TSPO: A Molecular Simulation Study.

Zeineb Si Chaib, Alessandro Marchetto, Klevia Dishnica, Paolo Carloni, Alejandro Giorgetti, Giulia Rossetti

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. The Interplay of Cholesterol and Ligand Binding inMolecules (Basel, Switzerland) · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zeineb Si ChaibInstitute for Neuroscience and Medicine (INM-9) and Institute for Advanced Simulations (IAS-5) "Computational biomedicine", Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-8008-8342
Alessandro MarchettoInstitute for Neuroscience and Medicine (INM-9) and Institute for Advanced Simulations (IAS-5) "Computational biomedicine", Forschungszentrum Jülich, 52425 Jülich, Germany.
Klevia DishnicaDepartment of Biotechnology, University of Verona, 37134 Verona, Italy.
Paolo CarloniInstitute for Neuroscience and Medicine (INM-9) and Institute for Advanced Simulations (IAS-5) "Computational biomedicine", Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-9010-0149
Alejandro GiorgettiInstitute for Neuroscience and Medicine (INM-9) and Institute for Advanced Simulations (IAS-5) "Computational biomedicine", Forschungszentrum Jülich, 52425 Jülich, Germany.
Giulia RossettiInstitute for Neuroscience and Medicine (INM-9) and Institute for Advanced Simulations (IAS-5) "Computational biomedicine", Forschungszentrum Jülich, 52425 Jülich, Germany.ORCID 0000-0002-2032-4630

Funding

Horizon 2020 Framework Programme 945539
6 · The paper itself

Abstract

The translocator protein (TSPO) is a transmembrane protein present across the three domains of life. Its functional quaternary structure consists of one or more subunits. In mice, the dimer-to-monomer equilibrium is shifted in vitro towards the monomer by adding cholesterol, a natural component of mammalian membranes. Here, we present a coarse-grained molecular dynamics study on the

Indexed as

Molecular Dynamics SimulationAnimalsBinding SitesCholesterolDimerizationMicePrincipal Component AnalysisProtein Structure, TertiaryReceptors, GABAStatic ElectricityBzrp protein, mouseCholesterolReceptors, GABAcholesterolMartini force-fieldTSPO

Identifiers

PMID32961709
PMCPMC7570527

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.