Evidence map›Paper›PMID 32961653›Full record

ArticleBiomolecules2020

Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells.

Kateryna Ohui, Iryna Stepanenko, Iuliana Besleaga, Maria V Babak, Radu Stafi, Denisa Darvasiova, Gerald Giester, Vivien Pósa, Eva A Enyedy, Daniel Vegh and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 6 countries.

Kateryna OhuiInstitute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria.
Iryna StepanenkoInstitute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria.
Iuliana BesleagaInstitute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria.
Maria V BabakDepartment of Chemistry, National University of Singapore, 3 Science Drive 2, Singapore 117543, Singapore.ORCID 0000-0002-2009-7837
Radu StafiInstitute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria.
Denisa DarvasiovaInstitute of Physical Chemistry and Chemical Physics, Slovak University of Technology in Bratislava, Radlinského 9, SK-81237 Bratislava, Slovakia.
Gerald GiesterDepartment of Mineralogy and Crystallography, University of Vienna, Althan Strasse 14, A-1090 Vienna, Austria.
Vivien PósaDepartment of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary.
Eva A EnyedyDepartment of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary.ORCID 0000-0002-8058-8128
Daniel VeghInstitute of Organic Chemistry, Catalysis and Petrochemistry, Department of Organic Chemistry, Slovak University of Technology in Bratislava, Radlinského 9, SK-81237 Bratislava, Slovakia.
Peter RaptaInstitute of Physical Chemistry and Chemical Physics, Slovak University of Technology in Bratislava, Radlinského 9, SK-81237 Bratislava, Slovakia.ORCID 0000-0001-6071-3932
Wee Han AngDepartment of Chemistry, National University of Singapore, 3 Science Drive 2, Singapore 117543, Singapore.
Ana Popović-BijelićFaculty of Physical Chemistry, University of Belgrade, 11158 Belgrade, Serbia.ORCID 0000-0003-3121-2391
Vladimir B ArionInstitute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria.
University of Vienna · ATSlovak University of Technology in Bratislava · SKNational University of Singapore · SGUniversity of Szeged · HUUniversity of Belgrade · RS

Funding

Austrian Science Fund P28223-N34
6 · The paper itself

Abstract

Thiosemicarbazones continue to attract the interest of researchers as potential anticancer drugs. For example, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, or triapine, is the most well-known representative of this class of compounds that has entered multiple phase I and II clinical trials. Two new triapine derivatives

Indexed as

AldehydesAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalCoordination ComplexesCopperCrystallography, X-RayElectrochemical TechniquesHEK293 CellsHumansMolecular StructurePyridinesSpectrophotometryThiosemicarbazones3-aminopyridine-2-carboxaldehyde thiosemicarbazoneAldehydesAntineoplastic AgentsCoordination ComplexesCopperpyridine-2-carboxaldehydePyridinesThiosemicarbazonesamidrazonescancer signallingcopper(II)iron(III)isothiosemicarbazonestriapine

Identifiers

PMID32961653
PMCPMC7564244
OpenAlexW3087753821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.