Evidence map›Paper›PMID 32961610›Full record

ArticleJournal of diabetes investigation2021

Prevalence of non-alcoholic fatty liver disease and factors associated with it in Indian women with a history of gestational diabetes mellitus.

Suraj Kubihal, Yashdeep Gupta, Shalimar, Devasenathipathy Kandasamy, Alpesh Goyal, Mani Kalaivani, Ankur Goyal, Saurabh Kedia, Garima Kachhawa, Samita Ambekar and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Prevalence of Hepatic Steatosis and Fibrosis in Asian Indian Individuals with Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
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  16. Overt Diabetes in Pregnancy.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022
    Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Suraj KubihalDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Yashdeep GuptaDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-4345-717X
ShalimarDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Devasenathipathy KandasamyDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
Alpesh GoyalDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0003-0922-5022
Mani KalaivaniDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Ankur GoyalDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
Saurabh KediaDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Garima KachhawaDepartment of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.
Samita AmbekarDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Divya BhatiaDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Vineeta GargDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Nandita GuptaDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Nikhil TandonDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0003-4604-1986
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionThis study aims to evaluate the prevalence of and factors associated with non-alcoholic fatty liver disease (NAFLD) in Indian women with prior gestational diabetes mellitus (GDM) diagnosed using International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. MATERIALS AND

methodsThis cross-sectional study (2018-2019) enrolled women with and without prior GDM. Study participants underwent detailed assessments, including relevant medical, obstetric and demographic details; 75-g oral glucose tolerance test with glucose and insulin estimation at 0, 30 and 120 min; and other relevant biochemical and anthropometric measurements. NAFLD status was defined by ultrasonography.

resultsWe evaluated a total of 309 women (201 and 108 with and without prior GDM, respectively) at a mean age of 31.9 ± 5.0 years and median of 16 months (interquartile range 9-38 months) following the index delivery. The prevalence of NAFLD was significantly higher in women with prior GDM (62.7% vs 50.0%, P = 0.038; grade 2 and 3 disease, 13.9% vs 6.5%). On logistic regression analysis (fully adjusted model), the odds of NAFLD were 2.11-fold higher in women with prior GDM (95% confidence interval 1.16-3.85, P = 0.014). Overweight/obesity, metabolic syndrome, prediabetes and homeostasis model of assessment of insulin resistance (a measure of insulin resistance) were positively associated with NAFLD, whereas the Matsuda index (a measure of insulin sensitivity) showed a negative association with NAFLD.

conclusionsThe prevalence of NAFLD is high in women with prior GDM. Such women also have a high burden of cardiometabolic risk factors. Future studies should evaluate the intermediate and long-term hepatic and cardiovascular risk, and the impact of lifestyle interventions in reducing morbidity in such women.

Indexed as

AdultCardiometabolic Risk FactorsCross-Sectional StudiesDelivery, ObstetricDiabetes, GestationalFemaleGlucose Tolerance TestHumansIndiaInsulin ResistanceLogistic ModelsMetabolic SyndromeNon-alcoholic Fatty Liver DiseaseObesityPrediabetic StatePregnancyGestational diabetes mellitusInternational Association of Diabetes and Pregnancy Study Groups criteriaNon-alcoholic fatty liver disease

Identifiers

PMID32961610
PMCPMC8089012
OpenAlexW3088999379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.