Evidence map›Paper›PMID 32961542›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Memantine effects on auditory discrimination and training in schizophrenia patients.

Neal R Swerdlow, Savita G Bhakta, Jo Talledo, Juliana Kotz, Benjamin Z Roberts, Royce Ellen Clifford, Michael L Thomas, Yash B Joshi, Juan L Molina, Gregory A Light

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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  13. An NIMH Workshop on Non-Affective Psychosis in Midlife and Beyond: Research Agenda on Phenomenology, Clinical Trajectories, Underlying Mechanisms, and Intervention Targets.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Neal R SwerdlowDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA. nswerdlow@health.ucsd.edu.ORCID http://orcid.org/0000-0001-9711-5020
Savita G BhaktaDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5560-8011
Jo TalledoDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Juliana KotzDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Benjamin Z RobertsDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Royce Ellen CliffordDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Michael L ThomasDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Yash B JoshiDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Juan L MolinaDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Gregory A LightDepartment of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
University of California San Diego · USColorado State University · US

Funding

Psychiatry Research Residency Training TrackR25MH101072 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEAL R SWERDLOW · 2013 to 2026
$2.8M
Memantine effects on sensorimotor gating and neurocognition in schizophreniaR01MH094320 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 2012 to 2020
$2.6M
NIMH NIH HHS R01 MH094320NIMH NIH HHS R25 MH101072RRD VA IK2 RX003395
6 · The paper itself

Abstract

The uncompetitive low-affinity NMDA receptor antagonist, memantine, acutely increases electrophysiological measures of auditory information processing in both healthy subjects (HS) and patients with schizophrenia. Memantine effects on functional measures of auditory discrimination performance and learning are not known; conceivably, beneficial effects on these measures might suggest a role for memantine in augmenting the cognitive and functional impact of auditory targeted cognitive training (TCT). Here, carefully characterized HS (n = 20) and schizophrenia patients (n = 22) were tested in measures of auditory discrimination performance (words-in-noise (WIN), quick speech-in-noise (QuickSIN), gaps-in-noise) and auditory frequency modulation learning (a component of TCT) on 2 days about a week apart, after ingesting either placebo or 20 mg memantine po, in a double-blind, within-subject cross-over random order design. Memantine modestly enhanced functional measures of auditory discrimination in both schizophrenia patients (WIN) and HS (WIN and QuickSIN), as well as auditory frequency modulation learning in schizophrenia patients. These findings converge with a growing literature showing that memantine can enhance a range of metrics of auditory function. These properties could contribute to the apparent benefits of memantine as an adjunctive treatment in schizophrenia, and suggest that memantine might augment learning and potentially clinical gains from auditory-based TCT.

Indexed as

MemantineSchizophreniaAuditory PerceptionDiscrimination, PsychologicalDouble-Blind MethodHumansReceptors, N-Methyl-D-AspartateMemantineReceptors, N-Methyl-D-Aspartate

Identifiers

PMID32961542
PMCPMC7784956
OpenAlexW3087891950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.