Evidence map›Paper›PMID 32961383›Full record

ReviewCurrent opinion in cell biology2021

Mitochondrial dynamics: Shaping and remodeling an organelle network.

Adam R Fenton, Thomas A Jongens, Erika L F Holzbaur

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

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  19. Self-renewal of neuronal mitochondria through asymmetric division.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam R FentonDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Thomas A JongensDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Erika L F HolzbaurDepartment of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: holzbaur@pennmedicine.upenn.edu.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
VANADIUM INTERACTION STUDIES IN RELATION TO THE INHIBITION OF NA+-K+-ATPASES06GM008216 · NIGMS · UNIVERSITY OF PUERTO RICO AT HUMACAO · PI ALEGRIA, ANTONIO E · 1989 to 2010
$8.0M
Integrative mechanisms of organelle dynamics from the atomic-to-cellular levelRM1GM136511 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DOMINGUEZ, ROBERTO, HOLZBAUR, ERIKA L · 2020 to 2024
$7.4M
Molecular Mechanisms of Axonal Transport and Organelle DynamicsR35GM126950 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Erika L Holzbaur · 2018 to 2026
$5.6M
Investigating a positive biological role for the A Beta peptideR21AG064618 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JONGENS, THOMAS A · 2019 to 2020
$446k
Determining whether metabolic and mitochondrial pathophysiology are a common feature of three distinct genetic models of ASDR21MH126257 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI JONGENS, THOMAS A · 2022 to 2023
$439k
NIA NIH HHS R21 AG064618NIGMS NIH HHS R35 GM126950NIGMS NIH HHS RM1 GM136511NIGMS NIH HHS S06 GM008216NIGMS NIH HHS T32 GM008216NIMH NIH HHS R21 MH126257
6 · The paper itself

Abstract

Mitochondria form networks that continually remodel and adapt to carry out their cellular function. The mitochondrial network is remodeled through changes in mitochondrial morphology, number, and distribution within the cell. Mitochondrial dynamics depend directly on fission, fusion, shape transition, and transport or tethering along the cytoskeleton. Over the past several years, many of the mechanisms underlying these processes have been uncovered. It has become clear that each process is precisely and contextually regulated within the cell. Here, we discuss the mechanisms regulating each aspect of mitochondrial dynamics, which together shape the network as a whole.

Indexed as

Mitochondrial DynamicsAnimalsCytoskeletonHumansMitochondriaMitochondrial MembranesMitochondrial ProteinsOrganelle ShapeMitochondrial ProteinsCytoskeletonFissionFusionMitochondriaMorphologyTransport

Identifiers

PMID32961383
PMCPMC7925334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.