Evidence map›Paper›PMID 32961201›Full record

ArticleJournal of molecular and cellular cardiology2020

Circadian influence on the microbiome improves heart failure outcomes.

Priya Mistry, Cristine J Reitz, Tarak Nath Khatua, Mina Rasouli, Kaitlyn Oliphant, Martin E Young, Emma Allen-Vercoe, Tami A Martino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Priya MistryCentre for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Cristine J ReitzCentre for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Tarak Nath KhatuaCentre for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Mina RasouliCentre for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Kaitlyn OliphantDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Martin E YoungDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Emma Allen-VercoeDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Tami A MartinoCentre for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. Electronic address: tmartino@uoguelph.ca.
University of Guelph · CAUniversity of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
Metabolic Rhythm Alterations as a Cause for Obesity CardiomyopathyR01HL149159 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL149159NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Myocardial infarction (MI) leading to heart failure (HF) is a major cause of death worldwide. Previous studies revealed that the circadian system markedly impacts cardiac repair post-MI, and that light is an important environmental factor modulating the circadian influence over healing. Recent studies suggest that gut physiology also affects the circadian system, but how it contributes to cardiac repair post-MI and in HF is not well understood. To address this question, we first used a murine coronary artery ligation MI model to reveal that an intact gut microbiome is important for cardiac repair. Specifically, gut microbiome disruption impairs normal inflammatory responses in infarcted myocardium, elevates adverse cardiac gene biomarkers, and leads to worse HF outcomes. Conversely, reconstituting the microbiome post-MI in mice with prior gut microbiome disruption improves healing, consistent with the notion that normal gut physiology contributes to cardiac repair. To investigate a role for the circadian system, we initially utilized circadian mutant Clock

Indexed as

Gastrointestinal MicrobiomeAnimalsCircadian RhythmCLOCK ProteinsHeart FailureHemodynamicsInflammationLeukocytesMaleMetabolomeMice, Inbred C57BLMyocardial InfarctionVentricular RemodelingCLOCK ProteinsCardiovascularCircadianInflammationMicrobiomeMyocardial infarctionRemodeling

Identifiers

PMID32961201
PMCPMC11027088
OpenAlexW3088880703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.