ArticleCell stem cell2021
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs.
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Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 63 citations in OpenAlex.
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- Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Molecular characterization of directly reprogrammed neurons from human fibroblasts using single cell RNA sequencing.Scientific reports · 2026Article
- MBNL1-dependent alternative splicing promotes neuronal differentiation through regulation of NUMA1 exon 16 during fibroblast-to-neuron reprogramming.Frontiers in cell and developmental biology · 2026Article
- Nicheformer: a foundation model for single-cell and spatial omics.Nature methods · 2025Article
- Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons.bioRxiv : the preprint server for biology · 2025Article
- Proliferation history and transcription factor levels drive direct conversion to motor neurons.Cell systems · 2025Article
- Serum-tolerant polymeric complex for stem-cell transfection and neural differentiation.Nature communications · 2025Article
- Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs.Cell reports · 2025Article
- The effect of LARP7 on gene expression during osteogenesis.Molecular biology reports · 2025Article
- Epigenetic Dynamics in Reprogramming to Dopaminergic Neurons for Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming.Science (New York, N.Y.) · 2024Article
- Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina.Science advances · 2024Article
- Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversion.Cell death & disease · 2024Article
- Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy.Genome research · 2024Article
- Parallel gene size and isoform expansion of ancient neuronal genes.Current biology : CB · 2024Article
- Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration.Nature aging · 2024Article
- The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention.Oncogene · 2024Review
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Authors and funding
16 authors at 1 institution in 1 country.
Kitra CatesDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Molecular Genetics and Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Matthew J McCoyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Molecular Genetics and Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ji-Sun KwonDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Computational and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yangjian LiuDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Daniel G AbernathyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Developmental, Regenerative, and Stem Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bo ZhangDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shaopeng LiuDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Paul GontarzDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Woo Kyung KimDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shawei ChenDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wenjun KongDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Computational and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua N HoDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Developmental, Regenerative, and Stem Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kyle F BurbachDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Molecular Genetics and Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Harrison W GabelDepartment of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Samantha A MorrisDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew S YooDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yooa@wustl.edu.
Washington University in St. Louis · US
Funding
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MTraining Program in Cellular and Molecular BiologyT32GM139774 · NIGMS · WASHINGTON UNIVERSITY · PI HEATHER L TRUE-KROB · 2021 to 2026
$6.7MMICRORNA AND NEURAL FACTOR-MEDIATED DIRECT REPROGRAMMING OF CELL FATESDP2NS083372 · NINDS · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2012 to 2017
$2.7MTraining At The Interface of Psychology, Neuroscience, and GeneticsT32GM081739 · NIGMS · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2007 to 2016
$2.1MModeling Neuronal Aging and Alzheimer's Disease in Human Neurons Directly Converted from FibroblastsRF1AG056296 · NIA · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2017 to 2017
$1.9MMechanistic insights into neurodegeneration in Huntington's disease using patient-derived neurons through direct conversion of fibroblastsR01NS107488 · NINDS · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2018 to 2022
$1.7MDISSECTING THE MECHANISM OF PIONEER TRANSCRIPTION FACTOR-MEDIATED LINEAGE REPROGRAMMINGR01GM126112 · NIGMS · WASHINGTON UNIVERSITY · PI MORRIS, SAMANTHA ANNETTE · 2017 to 2021
$1.6MNIA NIH HHS RF1 AG056296NIGMS NIH HHS R01 GM126112NIGMS NIH HHS T32 GM007067NIGMS NIH HHS T32 GM081739NIGMS NIH HHS T32 GM139774NINDS NIH HHS DP2 NS083372NINDS NIH HHS R01 NS107488
Abstract
Cell-fate conversion generally requires reprogramming effectors to both introduce fate programs of the target cell type and erase the identity of starting cell population. Here, we reveal insights into the activity of microRNAs miR-9/9
Indexed as
MicroRNAsCell DifferentiationCellular ReprogrammingChromatinFibroblastsHumansTranscription FactorsChromatinMicroRNAsTranscription Factorscell fatechromatin regulationdirect conversionepigeneticsmicroRNAneuronal reprogrammingnon-coding RNAsingle-cell RNA-sequencing
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.