ArticleCell metabolism2020
Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle.
Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
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- Modeling lipid homeostasis using stable isotope tracing and flux analysis.Cell metabolism · 2026Article
- The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting.Journal of biomedical science · 2025Review
- Glucose Metabolism, Lactate, Lactylation and Alzheimer's Disease.Aging and disease · 2025Review
- Simultaneous in vivo multi-organ fluxomics reveals divergent metabolic adaptations in liver, heart, and skeletal muscle during obesity.Cell reports · 2025Article
- Mechanisms for Regulatory Effects of Exercise on Metabolic Diseases from the Lactate-Lactylation Perspective.International journal of molecular sciences · 2025Review
- Quantitation of metabolic activity from isotope tracing data using automated methodology.Nature metabolism · 2024Article
- AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.Cell research · 2024Article
- Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment Strategies.Metabolites · 2024Review
- Metabolic rewiring and communication in cancer immunity.Cell chemical biology · 2024Review
- Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus.Cold Spring Harbor perspectives in medicine · 2023Article
- Study on the metabolic process of phthalic acid driven proliferation ofFrontiers in plant science · 2023Article
- Glycolytic metabolism supports microglia training during age-related neurodegeneration.Pharmacological reports : PR · 2022Review
- Tracing metabolic flux in vivo: basic model structures of tracer methodology.Experimental & molecular medicine · 2022Review
- Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila.Nature communications · 2022Article
- Integrative metabolic flux analysis reveals an indispensable dimension of phenotypes.Current opinion in biotechnology · 2022Review
- Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance.The EMBO journal · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The nutritional source for catabolism in the tricarboxylic acid (TCA) cycle is a fundamental question in metabolic physiology. Limited by data and mathematical analysis, controversy exists. Using isotope-labeling data in vivo across several experimental conditions, we construct multiple models of central carbon metabolism and develop methods based on metabolic flux analysis (MFA) to solve for the preferences of glucose, lactate, and other nutrients used in the TCA cycle. We show that in nearly all circumstances, glucose contributes more than lactate as a substrate to the TCA cycle. This conclusion is verified in different animal strains from different studies and different administrations of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.