Trial reportAnalytical chemistry2020
Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation.
Abstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomics profile in diabetes and blood glucose regulation: a systematic review.Frontiers in nutrition · 2026Pooled it
- Navigating the glycomics landscape with CE-MS: advances in sample preparation and analytical strategies.The Analyst · 2026Review
- Scientific and operational maturity of CE-MS: are we close?Trends in biotechnology · 2026Review
- A Software Tool for Rapid and Automated Preprocessing of Large-Scale Serum Metabolomic Data by Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry.Analytical chemistry · 2025Article
- CE-MS-Based Clinical Metabolomics of Human Plasma.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Review
- Development and Validation of RoboCap, a Robotic Capillary Platform to Automate Capillary Electrophoresis Mass Spectrometry En Route to High-Throughput Single-Cell Proteomics.Analytical chemistry · 2024Article
- Analysis of nanomaterial biocoronas in biological and environmental surroundings.Nature protocols · 2024Review
- [Progress of highly reproducible capillary electrophoresis].Se pu = Chinese journal of chromatography · 2024Article
- [Coupling capillary electrophoresis-electrospray ionization mass spectrometry with sheathless interface for drug analysis].Se pu = Chinese journal of chromatography · 2023Article
- Zero-Degree Celsius Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry.Analytical chemistry · 2023Article
- Profiling of polar ionogenic metabolites in Polish wines by capillary electrophoresis-mass spectrometry.Electrophoresis · 2022Article
- Understanding the Significance of Sample Preparation in Studies of the Nanoparticle Metabolite Corona.ACS measurement science au · 2022Article
- Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing (Frog) Embryo.Journal of visualized experiments : JoVE · 2022Article
- Profiling acidic metabolites by capillary electrophoresis-mass spectrometry in low numbers of mammalian cells using a novel chemical derivatization approach.Analytical science advances · 2022Article
- Capillary Electrophoresis Mass Spectrometry for Scalable Single-Cell Proteomics.Frontiers in chemistry · 2022Article
- Single-Cell Mass Spectrometry of Metabolites and Proteins for Systems and Functional Biology.Neuromethods · 2022Article
- Current applications of capillary electrophoresis-mass spectrometry for the analysis of biologically important analytes in urine (2017 to mid-2021): A review.Journal of separation science · 2022Review
- New insights into the conversion of electropherograms to the effective electrophoretic mobility scale.Electrophoresis · 2021Review
- [Annual review of capillary electrophoresis technology in 2020].Se pu = Chinese journal of chromatography · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors.
Nicolas DrouinDivision of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2311 G Leiden, The Netherlands.
Marlien van MeverDivision of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2311 G Leiden, The Netherlands.
Wei ZhangDivision of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2311 G Leiden, The Netherlands.ORCID 0000-0002-8320-3959
Elena TobolkinaSchool of Pharmaceutical Sciences, University of Geneva, Rue Michel Servet 1, 1211 4 Geneva, Switzerland.
Sabrina FerreSchool of Pharmaceutical Sciences, University of Geneva, Rue Michel Servet 1, 1211 4 Geneva, Switzerland.
Anne-Catherine ServaisLaboratory for the Analysis of Medicines, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Avenue Hippocrate 15, B-4000 Liège, Belgium.
Marie-Jia GouLaboratory for the Analysis of Medicines, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Avenue Hippocrate 15, B-4000 Liège, Belgium.
Laurent NyssenLaboratory for the Analysis of Medicines, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Avenue Hippocrate 15, B-4000 Liège, Belgium.
Marianne FilletLaboratory for the Analysis of Medicines, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Avenue Hippocrate 15, B-4000 Liège, Belgium.
Guinevere S M Lageveen-KammeijerLeiden University Medical Center, Center for Proteomics and Metabolomics, 2300 RC Leiden, The Netherlands.ORCID 0000-0001-7670-1151
Jan NoutaLeiden University Medical Center, Center for Proteomics and Metabolomics, 2300 RC Leiden, The Netherlands.
Andrew J ChetwyndSchool of Geography Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID 0000-0001-6648-6881
Iseult LynchSchool of Geography Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID 0000-0003-4250-4584
James A ThornAB Sciex UK Ltd, Phoenix House, Lakeside Drive, Warrington, Cheshire WA1 1RX, U.K.
Jens MeixnerAgilent Technologies R&D and Marketing GmbH & Co. KG, Hewlett-Packard-Straße 8, 76337 Waldbronn, Germany.
Christopher LößnerAB Sciex, Landwehrstrasse 54, 64293 Darmstadt, Germany.
Myriam TavernaUniversité Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France.
Sylvie LiuUniversité Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France.
N Thuy TranUniversité Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France.
Yannis FrancoisLaboratoire de Spectromètrie de Masse des Interactions et des Systémes (LSMIS) UMR 7140 (Unistra-CNRS), Université de Strasbourg, 4 Rue Blaise Pascal, 67081 CEDEX Strasbourg, France.ORCID 0000-0002-8776-071X
Antony LechnerLaboratoire de Spectromètrie de Masse des Interactions et des Systémes (LSMIS) UMR 7140 (Unistra-CNRS), Université de Strasbourg, 4 Rue Blaise Pascal, 67081 CEDEX Strasbourg, France.
Reine NehméInstitut de Chimie Organique et Analytique (ICOA), CNRS FR 2708 - UMR 7311, Université d'Orléans, 45067 Orléans, France.
Ghassan Al Hamoui Dit BanniInstitut de Chimie Organique et Analytique (ICOA), CNRS FR 2708 - UMR 7311, Université d'Orléans, 45067 Orléans, France.
Rouba NasreddineInstitut de Chimie Organique et Analytique (ICOA), CNRS FR 2708 - UMR 7311, Université d'Orléans, 45067 Orléans, France.
Cyril ColasInstitut de Chimie Organique et Analytique (ICOA), CNRS FR 2708 - UMR 7311, Université d'Orléans, 45067 Orléans, France.ORCID 0000-0003-1651-6813
Herbert H LindnerInstitute of Clinical Biochemistry, Innsbruck Medical University, Innrain 80-82, A-6020 Innsbruck, Austria.ORCID 0000-0003-1262-9976
Klaus FaserlInstitute of Clinical Biochemistry, Innsbruck Medical University, Innrain 80-82, A-6020 Innsbruck, Austria.
Christian NeusüßFaculty of Chemistry, Aalen University, Beethovenstraße 1, 73430 Aalen, Germany.
Manuel NelkeFaculty of Chemistry, Aalen University, Beethovenstraße 1, 73430 Aalen, Germany.
Stefan LämmererFaculty of Chemistry, Aalen University, Beethovenstraße 1, 73430 Aalen, Germany.
Catherine PerrinInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS-UM-ENSCM, Université de Montpellier, 34093 CEDEX 5 Montpellier, France.
Claudia Bich-MuraccioleInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247-CNRS-UM-ENSCM, Université de Montpellier, 34093 CEDEX 5 Montpellier, France.
Coral BarbasCentre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilladel Monte 28660, Madrid, Spain.ORCID 0000-0003-4722-491X
Ángeles López GonzálvezCentre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilladel Monte 28660, Madrid, Spain.
Andras GuttmanHorváth Csaba Memorial Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Faculty of Medicine, Doctoral School of Molecular Medicine, University of Debrecen, 98 Nagyerdei Road, H-4032 Debrecen, Hungary.ORCID 0000-0002-7838-082X
Marton SzigetiHorváth Csaba Memorial Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Faculty of Medicine, Doctoral School of Molecular Medicine, University of Debrecen, 98 Nagyerdei Road, H-4032 Debrecen, Hungary.ORCID 0000-0001-5136-8479
Philip Britz-McKibbinDepartment of Chemistry and Chemical Biology, McMaster University, 1280 Main St. W., Hamilton, Ontario L8S 4M1, Canada.ORCID 0000-0001-9296-3223
Zachary KroezenDepartment of Chemistry and Chemical Biology, McMaster University, 1280 Main St. W., Hamilton, Ontario L8S 4M1, Canada.
Meera ShanmuganathanDepartment of Chemistry and Chemical Biology, McMaster University, 1280 Main St. W., Hamilton, Ontario L8S 4M1, Canada.
Peter NemesDepartment of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0002-4704-4997
Erika P PorteroDepartment of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Thomas HankemeierDivision of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2311 G Leiden, The Netherlands.ORCID 0000-0001-7871-2073
Santiago CodesidoSchool of Pharmaceutical Sciences, University of Geneva, Rue Michel Servet 1, 1211 4 Geneva, Switzerland.
Víctor González-RuizSchool of Pharmaceutical Sciences, University of Geneva, Rue Michel Servet 1, 1211 4 Geneva, Switzerland.ORCID 0000-0001-7204-2363
Serge RudazSchool of Pharmaceutical Sciences, University of Geneva, Rue Michel Servet 1, 1211 4 Geneva, Switzerland.
Rawi RamautarDivision of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, 2311 G Leiden, The Netherlands.ORCID 0000-0002-1673-4848
Funding
Sub-Cellular Mass Spectrometry Discoveries: Metabolic Encoding of the Embryonic Body PlanR35GM124755 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI Peter Nemes · 2017 to 2026
$3.8MNIGMS NIH HHS R35 GM124755
Abstract
Capillary zone electrophoresis-mass spectrometry (CE-MS) is a mature analytical tool for the efficient profiling of (highly) polar and ionizable compounds. However, the use of CE-MS in comparison to other separation techniques remains underrepresented in metabolomics, as this analytical approach is still perceived as technically challenging and less reproducible, notably for migration time. The latter is key for a reliable comparison of metabolic profiles and for unknown biomarker identification that is complementary to high resolution MS/MS. In this work, we present the results of a Metabo-ring trial involving 16 CE-MS platforms among 13 different laboratories spanning two continents. The goal was to assess the reproducibility and identification capability of CE-MS by employing effective electrophoretic mobility (μ
Indexed as
CationsDatabases, ChemicalElectrolytesElectrophoresis, CapillaryHumansMetabolomeMetabolomicsOrganic ChemicalsReproducibility of ResultsTandem Mass SpectrometryCationsElectrolytesOrganic Chemicals
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