Evidence map›Paper›PMID 32960980›Full record

Observational studyJournal of clinical pharmacology2021

Pilot Study of Peak Plasma Concentration After High-Dose Oral Montelukast in Children With Acute Asthma Exacerbations.

Donald H Arnold, Sara L Van Driest, Theodore F Reiss, Jennifer C King, Wendell S Akers

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05819541 (Dose Escalation Clinical Trial of High-dose Oral Montelukast to Inform Future RCT in Children With Acute Asthma Exacerbations), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05819541 phase2completednot on this mapstarted 2023, after this paper: background citation

Dose Escalation Clinical Trial of High-dose Oral Montelukast to Inform Future RCT in Children With Acute Asthma Exacerbations

TypeinterventionalSponsorVanderbilt University Medical CenterRan2023 to 2026Enrolled90ConditionsStatus AsthmaticusArmsMontelukast Oral Granules, Albuterol, Corticosteroid
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Donald H ArnoldDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0001-8694-4288
Sara L Van DriestDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Theodore F ReissNovo Ventures (US) Boston, Boston, Massachusetts, USA.
Jennifer C KingDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Wendell S AkersDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Vanderbilt University · USBoston De Novo Design (United States) · USLipscomb University · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
NCRR NIH HHS UL1 RR024975
6 · The paper itself

Abstract

Acute asthma exacerbations are primarily due to airway inflammation and remain one of the most frequent reasons for childhood hospitalizations. Although systemic corticosteroids remain the mainstay of therapy because of their anti-inflammatory properties, not all inflammatory pathways are responsive to systemic corticosteroids, necessitating hospital admission for further management. Cysteinyl leukotrienes (LTs) are proinflammatory mediators that play an important role in systemic corticosteroids non-responsiveness. Montelukast is a potent LT-receptor antagonist, and an intravenous preparation caused rapid, sustained improvement of acute asthma exacerbations in adults. We hypothesized that a 30-mg dose of oral montelukast achieves peak plasma concentrations (C

Indexed as

AcetatesAdministration, OralAnti-Asthmatic AgentsAsthmaBody WeightChildChild, PreschoolChromatography, LiquidCyclopropanesDose-Response Relationship, DrugFemaleHumansLeukotriene AntagonistsMalePatient AcuityPilot ProjectsAcetatesAnti-Asthmatic AgentsCyclopropanesLeukotriene AntagonistsmontelukastQuinolinesSulfidesTabletsasthmaleukotrienemontelukastpediatricspharmacokinetics

Identifiers

PMID32960980
PMCPMC7855781
OpenAlexW3088998099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.