Evidence map›Paper›PMID 32960963›Full record

ArticleThe Journal of experimental medicine2020

Mutations make gut antibodies promiscuous.

Emilie K Grasset, Andrea Cerutti

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Emilie K GrassetThe Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY.
Andrea CeruttiThe Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY.
Icahn School of Medicine at Mount Sinai · USInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
NIAID NIH HHS P01 AI061093
6 · The paper itself

Abstract

In this issue, Kabbert et al. (https://doi.org/10.1084/jem.20200275) show that intestinal antibodies from healthy subjects or patients with Crohn's disease cross-target diverse but distinct communities of the gut microbiota through a mechanism involving somatic hypermutation but not germline-encoded polyreactivity.

Indexed as

Crohn DiseaseGastrointestinal MicrobiomeMicrobiotaAdultHumansImmunoglobulin AMutationImmunoglobulin A

Identifiers

PMID32960963
PMCPMC7596828
OpenAlexW3089066772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.