ArticlePloS one2020
Test-retest reliability of spatial navigation in adults at-risk of Alzheimer's disease.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Virtual Reality and Serious Videogame-Based Instruments for Assessing Spatial Navigation in Alzheimer's Disease: A Systematic Review of Psychometric Properties.Neuropsychology review · 2025Pooled it
- Article
- Article
- Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype.Journal of neurology · 2025Article
- Test-retest reliability of visual and self-motion cue combination during navigation: Accuracy, variability, and cue weighting.Spatial cognition and computation · 2025Article
- Predicting real-world navigation performance from a virtual navigation task in older adults.PloS one · 2025Article
- Understanding Learning from EEG Data: Combining Machine Learning and Feature Engineering Based on Hidden Markov Models and Mixed Models.Neuroinformatics · 2024Article
- Spatial Orientation Assessment in the Elderly: A Comprehensive Review of Current Tests.Brain sciences · 2024Review
- Shorter self-reported sleep duration is associated with worse virtual spatial navigation performance in men.Scientific reports · 2024Article
- The relationship between object-based spatial ability and virtual navigation performance.PloS one · 2024Article
- Assessment of executive functions using a 3D-video game in children and adolescents with ADHD.Frontiers in psychiatry · 2024Article
- Feasibility and reliability of online vs in-person cognitive testing in healthy older people.PloS one · 2024Article
- Virtual Reality for the Rehabilitation of Acquired Cognitive Disorders: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Safety and feasibility of transcutaneous vagus nerve stimulation in mild cognitive impairment: VINCI-AD study protocol.BMC neurology · 2023Article
- Spatial orientation - a stable marker for vascular cognitive impairment?Cerebral circulation - cognition and behavior · 2023Article
- Novel 3-D action video game mechanics reveal differentiable cognitive constructs in young players, but not in old.Scientific reports · 2022Article
- How the environment shapes our ability to navigate.Clinical and translational medicine · 2022Article
- Spatial memory deficits in Alzheimer's disease and their connection to cognitive maps' formation by place cells and grid cells.Frontiers in behavioral neuroscience · 2022Review
- Memory precision of object-location binding is unimpaired inBrain communications · 2021Article
- Development and validation of the Spatial Navigation and Memory Questionnaire (SPAM).Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test-retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.