Evidence map›Paper›PMID 32960690›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Longitudinal monitoring of microglial/macrophage activation in ischemic rat brain using Iba-1-specific nanoparticle-enhanced magnetic resonance imaging.

Laurel O Sillerud, Yirong Yang, Lisa Y Yang, Kelsey B Duval, Jeffrey Thompson, Yi Yang

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  8. β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
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  18. Microglia, the brain's double agent.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Laurel O SillerudDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Yirong YangBRaIN Imaging Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Lisa Y YangDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Kelsey B DuvalDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Jeffrey ThompsonCenter for Memory and Aging, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Yi YangDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
University of New Mexico · US

Funding

Sphingosine 1 phosphate signaling in cerebral small vessel diseaseRF1NS110724 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, YI · 2020 to 2020
$2.6M
Longitudinal Monitor of Microglia Activation After Stroke with SPION-enhanced MRIR21NS091710 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI YANG, YI · 2015 to 2016
$416k
NINDS NIH HHS R21 NS091710NINDS NIH HHS RF1 NS110724
6 · The paper itself

Abstract

Microglial/macrophage activation plays a dual role in response to brain injury after a stroke, promoting early neuroinflammation and benefit for neurovascular recovery. Therefore, the dynamics of stroke-induced cerebral microglial/macrophage activation are of substantial interest. This study used novel anti-Iba-1-targeted superparamagnetic iron-platinum (FePt) nanoparticles in conjunction with magnetic resonance imaging (MRI) to measure the spatiotemporal changes of the microglial/macrophage activation in living rat brain for four weeks post-stroke. Ischemic lesion areas were identified and measured using T

Indexed as

AnimalsBrain IschemiaDisease Models, AnimalMacrophage ActivationMagnetic Resonance ImagingMaleMicrogliaNanoparticlesRatsIba-1-antibody-conjugated superparamagnetic iron–platinum nanoparticlesIschemic strokemagnetic resonance imagingmicroglial/macrophage activationneuroinflammation

Identifiers

PMID32960690
PMCPMC7687035
OpenAlexW3088586348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.