ArticleThe British journal of radiology2020
Prompt gamma imaging for the identification of regional proton range deviations due to anatomic change in a heterogeneous region.
Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A novel approach for spot boosting selection and treatment plan optimization to enhance prompt gamma monitoring of proton therapy.Physics and imaging in radiation oncology · 2026Article
- Feasibility of in-vivo 4D prompt-gamma treatment verification in proton therapy for pancreatic cancer.Physics and imaging in radiation oncology · 2026Article
- Validation of prompt gamma-ray spectroscopy for proton range verification in tissue-mimicking and porcine samples.Physics in medicine and biology · 2022Article
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Authors and funding
11 authors.
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Abstract
objectivesPrompt gamma (PG) imaging has previously been demonstrated for use in proton range verification of a brain treatment with a homogeneous target region. In this study, the feasibility of PG imaging to detect anatomic change within a heterogeneous region is presented.
methodsA prompt gamma camera recorded several fractions of a patient treatment to the base of skull. An evaluation CT revealed a decrease in sinus cavity filling during the treatment course. Comparison of PG profiles between measurement and simulation was performed to investigate range variations between planned and measured pencil beam spot positions.
resultsFor one field, an average over range of 3 mm due to the anatomic change could be detected for a subset of spots traversing the sinus cavity region. The two other fields appeared less impacted by the change but predicted range variations could not be detected. These results were partially consistent with the simulations of the evaluation CT.
conclusionWe report the first clinical application of PG imaging that detected some of the expected small regional proton range deviations due to anatomic change in a heterogeneous region. However, several limitations exist with the technology that may limit its sensitivity to detect range deviations in heterogeneous regions. ADVANCES IN KNOWLEDGE: We report on the first detection of range variations due to anatomic change in a heterogeneous region using PGI. The results confirm the feasibility of using PG-based range verification in highly heterogeneous target regions to identify deviations from the treatment plan.
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