Evidence map›Paper›PMID 32960504›Full record

ReviewAndrology2021

Coronavirus: A possible cause of reduced male fertility.

Chuan Huang, Xiren Ji, Wenjun Zhou, Zhenghui Huang, Xiangjie Peng, Liqing Fan, Ge Lin, Wenbing Zhu

Open access · bronzeAbstract readReview
In one paragraph

Review in Andrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. A Review of Recent Studies on the Effects of SARS-CoV-2 Infection and SARS-CoV-2 Vaccines on Male Reproductive Health.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Review
  9. Review
  10. Review
  11. Observational
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chuan HuangInstitute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China.
Xiren JiInstitute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China.
Wenjun ZhouInstitute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China.
Zhenghui HuangInstitute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China.
Xiangjie PengReproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.
Liqing FanInstitute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China.
Ge LinInstitute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China.
Wenbing ZhuInstitute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China.ORCID 0000-0002-9352-2785
Central South University · CNReproductive & Genetic Hospital CITIC-Xiangya · CN

Funding

China Postdoctoral Science Foundation 2019M661521
6 · The paper itself

Abstract

In lately December 2019, a novel coronavirus (SARS-CoV-2) outbreak occurred in Wuhan, PR China. It is a high contagious virus that has threatened human health worldwide. SARS-CoV-2 infection, termed COVID-19, causes rapidly developing lung lesions that can lead to multiple organ failure in a short period. Whenever a novel virus emerges, reproductive risk assessments should be performed after infection. In this review, we show that male fertility might be damaged by coronavirus associated with (i) direct cytopathic effects derived from viral replication and viral dissemination in the testis; and (ii) indirect damage to male fertility derived from immunopathology. In this review, we briefly describe the impaired fertility of humans and animals infected with coronaviruses to deduce the impact of the new coronavirus on male fertility. Together with information related to other coronaviruses, we extrapolate this knowledge to the new coronavirus SARS-CoV-2, which may have a significant impact on our understanding of the pathophysiology of this new virus.

Indexed as

FertilityReproductive HealthAnimalsHost-Pathogen InteractionsHumansInfertility, MaleMalePrognosisRisk AssessmentRisk FactorsSex FactorsUrogenital SystemcoronavirusfertilitymaleSARS-CoV-2testis

Identifiers

PMID32960504
PMCPMC7537192
OpenAlexW3087166932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.