Evidence map›Paper›PMID 32960419›Full record

ArticleBrain imaging and behavior2021

MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a translational system referencing a standardized ontology.

R Jarrett Rushmore, Sylvain Bouix, Marek Kubicki, Yogesh Rathi, Douglas L Rosene, Edward H Yeterian, Nikos Makris

Open access · greenAbstract read
In one paragraph

Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

R Jarrett RushmoreDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Sylvain BouixPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Marek KubickiPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Yogesh RathiPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Douglas L RoseneDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Edward H Yeterian *Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Nikos Makris *Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. nikos@cma.mgh.harvard.edu.ORCID http://orcid.org/0000-0003-0425-3315
Brigham and Women's Hospital · USBoston University · US

Funding

Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
High Resolution, Comprehensive Atlases of the Human Brain MorphologyR01MH112748 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN, KUBICKI, MAREK · 2018 to 2022
$4.1M
Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkeyRF1AG062831 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2019 to 2019
$3.7M
Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie RestrictionRF1AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2019 to 2019
$3.7M
Mentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817k
NIA NIH HHS R01 AG042512NIA NIH HHS RF1 AG043640NIA NIH HHS RF1 AG062831NIMH NIH HHS K24 MH116366NIMH NIH HHS R01 MH112748NIMH NIH HHS R01MH112748
6 · The paper itself

Abstract

Investigations of the rhesus monkey (Macaca mulatta) brain have shed light on the function and organization of the primate brain at a scale and resolution not yet possible in humans. A cornerstone of the linkage between non-human primate and human studies of the brain is magnetic resonance imaging, which allows for an association to be made between the detailed structural and physiological analysis of the non-human primate and that of the human brain. To further this end, we present a novel parcellation method and system for the rhesus monkey brain, referred to as the macaque Harvard-Oxford Atlas (mHOA), which is based on the human Harvard-Oxford Atlas (HOA) and grounded in an ontological and taxonomic framework. Consistent anatomical features were used to delimit and parcellate brain regions in the macaque, which were then categorized according to functional systems. This system of parcellation will be expanded with advances in technology and, like the HOA, will provide a framework upon which the results from other experimental studies (e.g., functional magnetic resonance imaging (fMRI), physiology, connectivity, graph theory) can be interpreted.

Indexed as

BrainMagnetic Resonance ImagingAnimalsBrain MappingMacaca mulattacortical parcellationHOAmacaque monkeymHOAMRIOntology

Identifiers

PMID32960419
PMCPMC8608281
OpenAlexW3087420426

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.