Evidence map›Paper›PMID 32960353›Full record

ArticleEJNMMI research2020

[

Emma Jussing, Li Lu, Jonas Grafström, Tetyana Tegnebratt, Fabian Arnberg, Helena Wållberg Rosik, Anders Wennborg, Staffan Holmin, Joachim Feldwisch, Sharon Stone-Elander

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. ACS omega · 2022
    Article
  5. Deciphering albumin-directed drug delivery by imaging.Advanced drug delivery reviews · 2022
    Review
  6. Novel smallFrontiers in oncology · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Emma JussingDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden. emma.jussing@ki.se.ORCID http://orcid.org/0000-0003-4697-732X
Li LuDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden.
Jonas GrafströmDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden.
Tetyana TegnebrattDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden.
Fabian ArnbergDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden.
Helena Wållberg RosikDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden.
Anders WennborgAffibody AB, SE17165, Solna, Sweden.
Staffan HolminDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden.
Joachim FeldwischAffibody AB, SE17165, Solna, Sweden.
Sharon Stone-ElanderDepartment of Clinical Neuroscience, Karolinska Institutet, SE17177, Stockholm, Sweden.
Karolinska University Hospital · SEAffibody (Sweden) · SEKarolinska Institutet · SE

Funding

Cancerfonden 130430VINNOVA 2010-00521
6 · The paper itself

Abstract

backgroundAlbumin is commonly used as a carrier platform for drugs to extend their circulatory half-lives and influence their uptake into tissues that have altered permeability to the plasma protein. The albumin-binding domain (ABD) protein, which binds in vivo to serum albumin with high affinity, has proven to be a versatile scaffold for engineering biopharmaceuticals with a range of binding capabilities. In this study, the ABD protein equipped with a mal-DOTA chelator (denoted ABY-028) was radiolabeled with gallium-68 (

resultsABY-028, produced by peptide synthesis in excellent purity and stored at - 20 °C, was stable for 24 months (end of study). [

conclusions[

Indexed as

Albumin-binding domain proteinCerebral infarctionExperimental tumorGallium-68Positron emission tomographyVascular permeability

Identifiers

PMID32960353
PMCPMC7509035
OpenAlexW3087096947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.