ArticleBrain structure & function2020
Neuroanatomical changes associated with age-related hearing loss and listening effort.
Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The impact of age-related hearing loss on structural neuroanatomy: A meta-analysis.Frontiers in neurology · 2022Pooled it
- Associations Between Self-Reported Workload and Measures of Speech Recognition in Adults Across the Lifespan.American journal of audiology · 2026Article
- Network Meta-Analysis of Cognitive Impairment and miRNA Expression in Alzheimer's Disease Patients with Hearing Loss: A Systematic Review and Cross-Validation.Journal of clinical medicine · 2026Review
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Associations of cumulative hearing and vision loss with depression among U.S. adults aged 50 and older: results from the health and retirement study.BMC psychiatry · 2025Article
- Associations between physiological indicators of cochlear deafferentation and listening effort in military Veterans with normal audiograms.Hearing research · 2025Article
- Brain structural alterations in vestibular schwannoma beyond tinnitus and hearing loss.Brain communications · 2025Article
- Auditory steady state response can predict declining EF in healthy elderly individuals.Frontiers in aging neuroscience · 2025Article
- Spatial selective auditory attention is preserved in older age but is degraded by peripheral hearing loss.Scientific reports · 2024Article
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.Brain : a journal of neurology · 2024Article
- Polygenic Risk Score-Based Association Analysis Identifies Genetic Comorbidities Associated with Age-Related Hearing Difficulty in Two Independent Samples.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Extended High-frequency Audiometry in the Elderly: A Narrative Review.The journal of international advanced otology · 2024Review
- Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.Biomedicines · 2024Article
- Heritability of cognitive abilities and regional brain structures in middle-aged to elderly East Asians.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Listening with an Ageing Brain - a Cognitive Challenge.Laryngo- rhino- otologie · 2023Review
- Test-Retest Reliability and the Role of Task Instructions when Measuring Listening Effort Using a Verbal Response Time Paradigm.Seminars in hearing · 2023Review
- The impact of a speaker's voice quality on auditory perception and cognition: a behavioral and subjective approach.Frontiers in psychology · 2023Article
- Hearing loss, depression, and cognition in younger and older adult CI candidates.Frontiers in neurology · 2023Article
- Elevated Pure Tone Thresholds Are Associated with Altered Microstructure in Cortical Areas Related to Auditory Processing and Attentional Allocation.Journal of Alzheimer's disease : JAD · 2023Article
- Age-related changes in the primary auditory cortex of newborn, adults and aging bottlenose dolphins (Frontiers in neuroanatomy · 2023Article
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Abstract
Age-related hearing loss is associated with a decrease in hearing abilities for high frequencies and therefore leads to impairments in understanding speech-in particular, under adverse listening conditions. Growing evidence suggests that age-related hearing loss is related to various neural changes, for instance, affecting auditory and frontal brain regions. How the decreased auditory input and the increased listening effort in daily life are associated with structural changes is less clear, since previous evidence is scarce and mostly involved low sample sizes. Hence, the aim of the current study was to investigate the impact of age-related untreated hearing loss and subjectively rated daily life listening effort on grey matter and white matter changes in a large sample of participants (n = 71). For that aim, we conducted anatomical MRI and diffusion tensor imaging (DTI) in elderly hard-of-hearing and age-matched normal-hearing participants. Our results showed significantly lower grey matter volume in the middle frontal cortex in hard-of-hearing compared to normal-hearing participants. Further, higher listening effort was associated with lower grey matter volume and cortical thickness in the orbitofrontal cortex and lower grey matter volume in the inferior frontal cortex. No significant relations between hearing abilities or listening effort were obtained for white matter integrity in tracts connecting auditory and prefrontal as well as visual areas. These findings provide evidence that hearing impairment as well as daily life listening effort seems to be associated with grey matter loss in prefrontal brain regions. We further conclude that alterations in cortical thickness seem to be linked to the increased listening effort rather than the hearing loss itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.