ArticleThe EMBO journal2020
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
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Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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123citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
123 citing papers in PubMed, 176 citations in OpenAlex.
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- IL-33/ST2 Signaling and Microglial Functional-State Transitions After Spinal Cord Injury: Direct Evidence and Mechanistic Hypotheses.International journal of molecular sciences · 2026Review
- The microglial TREM2 receptor programs hippocampal development in a mouse model of childhood deprivation.Brain, behavior, and immunity · 2026Article
- Microglia maintain retinal redox homeostasis following ablation of rod photoreceptors in zebrafish.The Journal of biological chemistry · 2026Article
- Wasteosomes (corpora amylacea) of the human brain accumulate in CD44-positive astrocytes.iScience · 2026Article
- PLX5622 did not alter anxiety-like behaviour and showed limited microglial depletion efficacy in a spinal cord injury model in female rats.Scientific reports · 2026Article
- Spared cognitive and social function following perinatal ablation of ATRX despite transient microglia dysregulation.Scientific reports · 2026Article
- Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy.Science (New York, N.Y.) · 2026Article
- Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes.Research square · 2026Article
- Neuroimmune Interactions in Neurodegeneration: The Role of Microglia in Alzheimer's and Parkinson's Disease Pathogenesis.Brain sciences · 2026Review
- Article
- Environmental Stressors and Neuroinflammation: Linking Climate Change to Alzheimer's Disease.Current issues in molecular biology · 2025Review
- Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes.bioRxiv : the preprint server for biology · 2025Article
- Beyond the gut: decoding the gut-immune-brain axis in health and disease.Cellular & molecular immunology · 2025Review
- TGF-β signaling regulates gene expression, phagocytosis, and cell proliferation and supports glial cell survival in primary rat mixed glial cell cultures.Journal of molecular histology · 2025Article
- Noninvasive Brain Stimulation Protects Cognitive Impairment in i.c.v. STZ-Injected Rats: Role of Adult Neurogenesis.The European journal of neuroscience · 2025Article
- Nasal Delivery of Engineered Exosomes via a Thermo-Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases.Molecular neurodegeneration · 2025Review
- NMDA receptor antagonists mitigate COVID-19-induced neuroinflammation and improve survival in a mouse model.Scientific reports · 2025Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 3 countries.
Hiroyuki KonishiDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-4321-8339
Takayuki OkamotoDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuichiro HaraDepartment of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Okiru KomineDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Hiromi TamadaDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Mitsuyo MaedaMulti-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center, Kobe, Japan.
Fumika OsakoDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masaaki KobayashiDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akira NishiyamaDepartment of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yosky KataokaMulti-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center, Kobe, Japan.
Toshiyuki TakaiDepartment of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Nobuyuki UdagawaDepartment of Biochemistry, Matsumoto Dental University, Shiojiri, Japan.
Steffen JungDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-4290-5716
Keiko OzatoDivision of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Tomohiko TamuraDepartment of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Makoto TsudaDepartment of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0003-0585-9570
Koji YamanakaDepartment of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.ORCID 0000-0003-4655-0035
Tomoo OgiDepartment of Genetics, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Katsuaki SatoDivision of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hiroshi KiyamaDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0001-5963-046X
Nagoya University · JPJEOL (Japan) · JPYokohama City University · JPKyushu University · JPMatsumoto Dental University · JPNational Institutes of Health · USTohoku University · JPUniversity of Miyazaki · JPWeizmann Institute of Science · IL
Funding
Ministry of Education, Culture, Sports, Science and Technology (MEXT) 16H05117Ministry of Education, Culture, Sports, Science and Technology (MEXT) 16K07055Ministry of Education, Culture, Sports, Science and Technology (MEXT) 17H05743Ministry of Education, Culture, Sports, Science and Technology (MEXT) 19H03395Ministry of Education, Culture, Sports, Science and Technology (MEXT) 19K06904Nasu Foundation
Abstract
Microglia are the principal phagocytes that clear cell debris in the central nervous system (CNS). This raises the question, which cells remove cell debris when microglial phagocytic activity is impaired. We addressed this question using Siglech
Indexed as
AnimalsAstrocytesBrainCentral Nervous SystemDisease Models, AnimalFemaleInterferon Regulatory Factor-8Interferon Regulatory FactorsMaleMiceMice, KnockoutMicrogliaPhagocytosisInterferon Regulatory Factor-8Interferon Regulatory FactorsastrocytedebrismicrogliaphagocytosisRNA-seq
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.