ArticleThe Journal of infectious diseases2021
Vertical Transmission: A Vector-Independent Transmission Pathway of Babesia microti in the Natural Reservoir Host Peromyscus leucopus.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Congenital babesiosis in China: first molecularly confirmed case of vertical transmission ofEmerging microbes & infections · 2026Article
- Babesia microti: Breaking the culture barrier.Trends in parasitology · 2026Review
- Coinfection ecology and pathogen emergence in aApplied and environmental microbiology · 2026Article
- Acquired motility ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- In Vitro Monitoring of Babesia microti Infection Dynamics in Whole Blood Microenvironments.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Functional connectivity for white-tailed deer drives the distribution of tick-borne pathogens in a highly urbanized setting.Landscape ecology · 2025Article
- Prevalence ofMicroorganisms · 2024Article
- Host-pathogen associations inferred from bloodmeal analyses ofApplied and environmental microbiology · 2024Article
- Detection of a novel Babesia sp. in Amblyomma javanense, an ectoparasite of Sunda pangolins.Parasites & vectors · 2023Article
- Transfusion-transmittedJournal of clinical microbiology · 2023Review
- Ecological interactions driving population dynamics of two tick-borne pathogens,Proceedings. Biological sciences · 2023Article
- Serum metabolomic profiles in BALB/c mice induced byFrontiers in cellular and infection microbiology · 2023Article
- What do we know about the microbiome ofFrontiers in cellular and infection microbiology · 2022Review
- The Global Emergence of Human Babesiosis.Pathogens (Basel, Switzerland) · 2021Review
- Article
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Authors and funding
2 authors.
Funding
Abstract
backgroundBabesia microti, a malaria-like pathogen, is increasing in mammal and human populations in endemic areas and is unlikely to be the sole result of horizontal pathogen transmission.
methodsPeromyscus leucopus mice, natural reservoir hosts, were infected via Ixodes scapularis nymphs. Infected parental females (n = 6) produced F1 offspring (n = 36) that were screened for B. microti using quantitative PCR. Xenodiagnostic larvae were fed on infected offspring to determine horizontal transmission and pathogen viability. Fifty engorged larvae were screened; the rest were allowed to molt and then screened to determine transstadial transmission. Infected F1 generation offspring were placed in breeding groups, producing 34 F2 offspring and screened for B. microti infection. Chronic infection was monitored in parental females since time of initial vector infection.
resultsVertical transmission of B. microti was 74% efficient in offspring born in the first 6 months. Horizontal transmission occurred in larvae (61% prevalence) and molted nymphs (58% prevalence); these nymphs were able to infect susceptible hosts. F2 generation offspring infection prevalence was 38%. Chronic infection persisted for 1 year in some adults.
conclusionsThese results demonstrate that vertical transmission is an important nonvector-mediated pathway of B. microti transmission in the natural reservoir host.
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