Evidence map›Paper›PMID 32959778›Full record

ArticleeLife2020

Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection.

Bryan L Gitschlag, Ann T Tate, Maulik R Patel

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Evolutionary dynamics within and among competing groups.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Bryan L GitschlagDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.
Ann T TateDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.ORCID 0000-0001-6601-0234
Maulik R PatelDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.ORCID 0000-0003-3749-0122

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Regulation of mitochondrial heteroplasmy dynamicsR01GM123260 · NIGMS · VANDERBILT UNIVERSITY · PI PATEL, MAULIK R · 2017 to 2021
$1.5M
Mechanisms underlying mutant mitochondrial genome dynamicsF31GM125344 · NIGMS · VANDERBILT UNIVERSITY · PI GITSCHLAG, BRYAN L. · 2017 to 2018
$57k
NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIGMS NIH HHS 1 F31 GM125344NIGMS NIH HHS F31 GM125344NIGMS NIH HHS GM123260NIGMS NIH HHS R01 GM123260NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cooperation and cheating are widespread evolutionary strategies. While cheating confers an advantage to individual entities within a group, competition between groups favors cooperation. Selfish or cheater mitochondrial DNA (mtDNA) proliferates within hosts while being selected against at the level of host fitness. How does environment shape cheater dynamics across different selection levels? Focusing on food availability, we address this question using heteroplasmic

Indexed as

AnimalsBiological EvolutionCaenorhabditis elegansCell ProliferationGenetic FitnessGenome, MitochondrialMitochondrial DynamicsNutrientsRepetitive Sequences, Nucleic AcidNutrientsC. eleganscheatingevolutionary biologygeneticsgenomicsheteroplasmymetabolismmitochondriamultilevel selectionnutrient availability

Identifiers

PMID32959778
PMCPMC7508553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.