SynthesisCartilage2021
Knee Intraosseous Injections: A Systematic Review of Clinical Evidence of Different Treatment Alternatives.
Synthesis in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Intra-Articular Injection of Botulinum Toxin for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials.International journal of molecular sciences · 2023Pooled it
- Intraosseous platelet-rich plasma for osteoarthritis: a comprehensive review.EFORT open reviews · 2026Review
- Subchondral Knee Injections: A Comprehensive Systematic Review of Current Clinical Outcomes, Safety, and Arthroplasty Delay.Cartilage · 2026Article
- Intra-articular and intra-osseous expanded adipose-derived stromal cell injections for knee osteoarthritis-related bone marrow lesions yield promising outcomes: Preliminary results in 16 athletes.Journal of experimental orthopaedics · 2026Article
- Subchondral Phosphate Injection During Hip Arthroscopy Safely Treats Acetabular Bone Marrow Lesions in Early Osteoarthritis.Journal of clinical medicine · 2025Article
- Plasma Rich in Growth Factors (PRGF) Versus Saline Intraosseous Infiltrations Combined with Intra-Articular PRGF in Severe Knee Osteoarthritis: A Prospective Double-Blind Multicentric Randomized Controlled Trial with 1-Year Follow-Up.Journal of clinical medicine · 2025Article
- Arthroscopic-Assisted Management of Subchondral Bone Marrow Lesions of the Knee.Arthroscopy techniques · 2025Article
- Article
- Intra-articular and intraosseous approach to temporomandibular joint-targeted injections: a cadaveric investigation.Journal of ultrasound · 2024Article
- Intraosseous Delivery of Mesenchymal Stem Cells for the Treatment of Bone and Hematological Diseases.Current issues in molecular biology · 2024Review
- Autologous microfragmented adipose tissue treatment of knee osteoarthritis demonstrates effectiveness in 68% of patients at 4-year follow-up.Archives of orthopaedic and trauma surgery · 2024Observational
- Intraosseous Treatment of Bone Marrow Lesions in the Knee: Surgical Technique.Arthroscopy techniques · 2024Article
- Mission (im)possible: meniscal preservation and cartilage regeneration.International orthopaedics · 2023Article
- Combined subchondral and intra-articular injections of bone marrow aspirate concentrate provide stable results up to 24 months.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Does Bone Marrow Edema Influence the Clinical Results of Intra-Articular Platelet-Rich Plasma Injections for Knee Osteoarthritis?Journal of clinical medicine · 2022Article
- Subchondral and intra-articular injections of bone marrow concentrate are a safe and effective treatment for knee osteoarthritis: a prospective, multi-center pilot study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Intraosseous Injections Are Safe And Effective in Knee Osteoarthritis: A Systematic Review.Arthroscopy, sports medicine, and rehabilitation · 2021Review
- Injections in the osteoarthritic knee: a review of current treatment options.EFORT open reviews · 2021Review
- Osteoarthritis: an ancient disease, an unsolved conundrum.International orthopaedics · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically review the available clinical evidence regarding the safety and efficacy of knee intraosseous injections for the treatment of bone marrow lesions in patients affected by knee osteoarthritis.
designA literature search was carried out on PubMed, Embase, and Google Scholar databases in January 2020. The following inclusion criteria were adopted: (1) studies of any level of evidence, dealing with subchondral injection of bone substitute materials and/or biologic agents; (2) studies with minimum 5 patients treated; and (3) studies with at least 6 months' follow-up evaluation. All relevant data concerning clinical outcomes, adverse events, and rate of conversion to arthroplasty were extracted.
resultsA total of 12 studies were identified: 7 dealt with calcium phosphate administration, 3 with platelet-rich plasma, and 2 with bone marrow concentrate injection. Only 2 studies were randomized controlled trials, whereas 6 studies were prospective and the remaining 4 were retrospective. Studies included a total of 459 patients treated with intraosseous injections. Overall, only a few patients experienced adverse events and clinical improvement was documented in the majority of trial. The lack of any comparative evaluation versus subchondral drilling alone is the main limitation of the available evidence.
conclusionsKnee intraosseous injections are a minimally invasive and safe procedure to address subchondral bone damage in osteoarthritic patients. They are able to provide beneficial effects at short-term evaluation. More high-quality evidence is needed to confirm their potential and to identify the best product to adopt in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.