SynthesisReviews in endocrine & metabolic disorders2021
The ultrasound risk stratification systems for thyroid nodule have been evaluated against papillary carcinoma. A meta-analysis.
Synthesis in Reviews in endocrine & metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- Malignancy Risk of Thyroid Nodules That Are Not Classifiable by the American Thyroid Association Ultrasound Risk Stratification System: A Systematic Review and Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2023Pooled it
- Suboptimal accuracy of ultrasound and ultrasound-based risk stratification systems in detecting medullary thyroid carcinoma should not be overlooked. Findings from a systematic review with meta-analysis.Clinical endocrinology · 2022Pooled it
- The dilemma ofEndocrine · 2021Pooled it
- Cancer prevalence in the subcategories of the indeterminate class III (AUS/FLUS) of the Bethesda system for thyroid cytology: a meta-analysis.Journal of endocrinological investigation · 2021Pooled it
- Artificial intelligence-based systems as auxiliary tools for thyroid nodule malignancy detection on ultrasound: a systematic review and meta-analysis of diagnostic accuracy.Gland surgery · 2026Article
- Increased Risk of Thyroid Cancer in Patients with Graves' Disease and Thyroid Nodules: A Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Evolving trends in pediatric thyroid nodules and cancer management.Annals of pediatric endocrinology & metabolism · 2026Article
- Analysis of FNAC indication in thyroid nodules assessed as low risk according to various TIRADSs.European thyroid journal · 2025Article
- Article
- Clinical management of indeterminate thyroid nodules needs to be revisited. New evidence for a personalized approach to the problem.Journal of endocrinological investigation · 2025Observational
- Complexity in the interpretation and application of multiple guidelines for thyroid nodules: the need for coordinated recommendations for "small" lesions.Reviews in endocrine & metabolic disorders · 2025Review
- The predictive value of the ultrasound grayscale ratio for identifying malignant thyroid nodules.Frontiers in endocrinology · 2025Article
- Explainable multi-modal machine learning for predicting occult pulmonary metastases in differentiated thyroid cancer: a SHAP-based approach prior to radioactive iodine scans.Frontiers in medical technology · 2025Article
- Diagnostic Nomogram Model for ACR TI-RADS 4 Nodules Based on Clinical, Biochemical Data and Sonographic Patterns.Clinical endocrinology · 2025Article
- Risk Stratification of Thyroid Nodules 10 mm in Diameter or Less: Strength and Pitfalls of the Ultrasonographic Assessment From a Cross-Sectional Study.International journal of endocrinology · 2025Article
- Performance of ACR-TIRADS in assessing thyroid nodules does not vary according to patient age.Hormones (Athens, Greece) · 2024Article
- The value of ACR, European, Korean, and ATA ultrasound risk stratification systems combined with RAS mutations for detecting thyroid carcinoma in cytologically indeterminate and suspicious for malignancy thyroid nodules.Hormones (Athens, Greece) · 2024Article
- The Horizon of Thyroid Imaging Reporting and Data System in the Diagnostic Performance of Thyroid Nodules: Clinical Application and Future Perspectives.TouchREVIEWS in endocrinology · 2024Review
- Application of microvascular ultrasound-assisted thyroid imaging report and data system in thyroid nodule risk stratification.Insights into imaging · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid imaging reporting and data systems (TIRADS) are used to stratify the malignancy risk of thyroid nodule by ultrasound (US) examination. We conducted a meta-analysis to evaluate the pooled cancer prevalence and the relative prevalence of papillary, medullary, follicular thyroid cancer (PTC, MTC, and FTC) and other malignancies among nodules included in studies evaluating their performance. Four databases were searched until February 2020. Original articles with at least 1000 nodules, evaluating the performance of at least one TIRADS among AACE/ACE/AME, ACR-TIRADS, ATA, EU-TIRADS, or K-TIRADS, and reporting data on the histological diagnosis of malignant lesions were included. The number of malignant nodules, PTC, FTC, MTC and other malignancies in each study was extracted. For statistical pooling of data, a random-effects model was used. Nine studies were included, evaluating 19,494 thyroid nodules. The overall prevalence of malignancy was 34% (95%CI 21 to 49). Among 6162 histologically proven malignancies, the prevalence of PTC, FTC, MTC and other malignancies was 95%, 2%, 1%, and 1%, respectively. A high heterogeneity was found for all the outcomes. A limited number of studies generally conducted using a retrospective design was found, with possible selection bias. Acknowledging this limitation, TIRADSs should be regarded as accurate tools to diagnose PTC only. Proposed patterns and/or cut-offs should be revised and other strategies considered to improve their performance in the assessment of FTC, MTC and other malignancies.
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