ReviewEuropean journal of nuclear medicine and molecular imaging2021
Clinical utility of perfusion (Q)-single-photon emission computed tomography (SPECT)/CT for diagnosing pulmonary embolus (PE) in COVID-19 patients with a moderate to high pre-test probability of PE.
Review in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- SPECT/CT Scan Images to Evaluate COVID-19 Pulmonary Complications: A Systematic Review.International journal of environmental research and public health · 2025Pooled it
- Perfusion-only Q-SPECT as a rule-out tool for CTEPH in resource-limited settings: a feasibility study on reducing unnecessary referrals to tertiary centers.BMC pulmonary medicine · 2026Article
- Recent Advancements in Radiopharmaceuticals for Infection Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Gallium-68 labelled RGD PET/CT imaging of endothelial activation in COVID-19 patients.Scientific reports · 2023Observational
- The Clinical Utility of Molecular Imaging in COVID-19: An Update.Seminars in nuclear medicine · 2023Review
- A novel intelligent radiomic analysis of perfusion SPECT/CT images to optimize pulmonary embolism diagnosis in COVID-19 patients.EJNMMI physics · 2022Article
- CMR Findings in COVID-19 Recovered Patients: A Review on Parametric Mapping, Feature-Tracking, and LGE.Reviews in cardiovascular medicine · 2022Review
- Imaging Pulmonary Blood Vessels and Ventilation-Perfusion Mismatch in COVID-19.Molecular imaging and biology · 2022Review
- Molecular imaging as a tool for evaluation of COVID-19 sequelae - A review of literature.World journal of radiology · 2022Review
- Lung Scintigraphy for Pulmonary Embolism Diagnosis in COVID-19 Patients: A Multicenter Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaFPharmaceutics · 2022Article
- Experience with a Perfusion-Only Screening Protocol for Evaluation of Pulmonary Embolism During the COVID-19 Pandemic Surge.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Safe Pulmonary Scintigraphy in the Era of COVID-19.Seminars in nuclear medicine · 2022Review
- Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives.Frontiers in medicine · 2022Review
- Lung Perfusion Scintigraphy Early After COVID-19: A Single-Center Retrospective Study.Journal of nuclear medicine technology · 2021Article
- Investigation of perfusion defects by Q-SPECT/CT in patients with mild-to-moderate course of COVID-19 and low clinical probability for pulmonary embolism.Annals of nuclear medicine · 2021Article
- The heterogeneity of lung perfusion patterns in SPECT/CT during COVID-19: not only embolism.European journal of nuclear medicine and molecular imaging · 2021Article
- A comprehensive review of imaging findings in COVID-19 - status in early 2021.European journal of nuclear medicine and molecular imaging · 2021Review
- V/Q SPECT/CT in the Time of COVID-19: Changing the Order to Improve Safety Without Sacrificing Accuracy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Article
- Imaging in the COVID-19 era: Lessons learned during a pandemic.World journal of radiology · 2021Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe reviewed the clinical utility of perfusion (Q)-single-photon emission computed tomography (SPECT)/CT for diagnosing pulmonary embolus (PE) in patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2).
methodsFollowing the World Health Organization's declaration of a global pandemic, our department policy recommended Q-only SPECT/CT for all patients undergoing nuclear medicine evaluation for suspected PE to reduce the risk of aerosolization of respiratory droplets. We performed a retrospective review of sequential patients admitted with COVID-19 imaged with Q-SPECT/CT between March 17, 2020, and June 30, 2020, at Memorial Sloan Kettering Cancer Center. We recorded patient demographics, clinical symptoms, Wells score (to stratify patients according to pre-test probability for PE prior to Q-SPECT/CT), and noted ancillary imaging findings on CT.
resultsOf the 33 patients imaged with Q-SPECT/CT, 6 patients (3 men, 3 women) had a laboratory confirmed diagnosis of COVID-19 (mean age, 55, ± 11.4 years, range 33-68). All patients had a current diagnosis of malignancy and had a moderate or high pre-test probability for PE (mean Wells score 2.8, range 2-4). Q-SPECT/CT was positive in 4/6 (67%) of patients. Distribution of pulmonary emboli was bilateral and segmental in 75% of patients. Ancillary acute findings on SPECT/CT included bilateral parenchymal ground glass opacities (n = 5), pleural effusions (n = 2), and pneumomediastinum (n = 1).
conclusionQ-SPECT/CT has clinical utility for diagnosing PE in patients with COVID-19 where there is a contraindication for iodinated contrast media and a moderate or high pre-test probability for PE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.