Evidence map›Paper›PMID 32959083›Full record

ArticleHuman genetics2021

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality.

Emmanuel O Adewuyi, Divya Mehta, Yadav Sapkota, International Endogene Consortium, 23andMe Research Team, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R Griffiths, Grant W Montgomery and 2 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Emmanuel O AdewuyiSchool of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD, Australia. emmanuel.adewuyi@qut.edu.au.ORCID http://orcid.org/0000-0002-4533-0340
Divya MehtaSchool of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD, Australia.
Yadav SapkotaDepartment of Epidemiology And Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
International Endogene Consortium
23andMe Research Team
Asa AutaSchool of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.
Kosuke YoshiharaDepartment of Obstetrics And Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 950-2181, Japan.
Mette NyegaardDepartment of Biomedicine - Human Genetics, Aarhus University, 8000, Aarhus,, Denmark.
Lyn R GriffithsSchool of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD, Australia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Daniel I ChasmanDivisions of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Dale R NyholtSchool of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD, Australia. d.nyholt@qut.edu.au.
Queensland University of Technology · AUAarhus University · DKBrigham and Women's Hospital · USNiigata University · JPSt. Jude Children's Research Hospital · USThe University of Queensland · AUUniversity of Lancashire · GB

Funding

National Health and Medical Research Council (AU) 1,050,208National Health and Medical Research Council (AU) 241,944, 339,462, 389,927, 389,875, 389,891, 389,892, 389,938, 443,036, 442,915, 442,981, 496,610, 496,739, 552,485, 552,498, 1,026,033The Lundbeck Foundation, Denmark R102-A9118The Lundbeck Foundation, Denmark R155-2014-1724Wellcome Trust 076113Wellcome Trust 085475
6 · The paper itself

Abstract

Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (P

Indexed as

DepressionEndometriosisFemaleGastric MucosaGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLinkage DisequilibriumPolymorphism, Single Nucleotide

Identifiers

PMID32959083
OpenAlexW3087605373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.