ArticleCerebral cortex (New York, N.Y. : 1991)2021
The Heritability of Cortical Folding: Evidence from the Human Connectome Project.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Blindness reveals that Heschl's gyrus folding is not altered by auditory experience.bioRxiv : the preprint server for biology · 2026Article
- Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns.Nature neuroscience · 2026Article
- Socioeconomic context influences the heritability of child cortical structure.Communications biology · 2025Article
- Socioeconomic context influences the heritability of child cortical structure.medRxiv : the preprint server for health sciences · 2025Article
- The Genetics of Cerebellar Structure and Associations With Cognitive Performance: A Twin Magnetic Resonance Imaging Study.Human brain mapping · 2025Article
- Genetic foundations of interindividual neurophysiological variability.Science advances · 2025Article
- Burst of gyrification in the human brain after birth.Communications biology · 2025Article
- Genetic Foundations of Inter-individual Neurophysiological Variability.bioRxiv : the preprint server for biology · 2025Article
- Article
- A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Alterations in sulcal depth and associated functional connectivity in schizophrenia with auditory verbal hallucinations.Frontiers in psychiatry · 2025Article
- Language aptitude is related to the anatomy of the transverse temporal gyri.Brain structure & function · 2024Article
- Article
- Increased brain gyrification and cortical thinning in winter-born patients with schizophrenia spectrum.Frontiers in psychiatry · 2024Article
- Shaping the brain: The emergence of cortical structure and folding.Developmental cell · 2023Review
- A critical period plasticity framework for the sensorimotor-association axis of cortical neurodevelopment.Trends in neurosciences · 2023Review
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4 authors.
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Abstract
The mechanisms underlying cortical folding are incompletely understood. Prior studies have suggested that individual differences in sulcal depth are genetically mediated, with deeper and ontologically older sulci more heritable than others. In this study, we examine FreeSurfer-derived estimates of average convexity and mean curvature as proxy measures of cortical folding patterns using a large (N = 1096) genetically informative young adult subsample of the Human Connectome Project. Both measures were significantly heritable near major sulci and primary fissures, where approximately half of individual differences could be attributed to genetic factors. Genetic influences near higher order gyri and sulci were substantially lower and largely nonsignificant. Spatial permutation analysis found that heritability patterns were significantly anticorrelated to maps of evolutionary and neurodevelopmental expansion. We also found strong phenotypic correlations between average convexity, curvature, and several common surface metrics (cortical thickness, surface area, and cortical myelination). However, quantitative genetic models suggest that correlations between these metrics are largely driven by nongenetic factors. These findings not only further our understanding of the neurobiology of gyrification, but have pragmatic implications for the interpretation of heritability maps based on automated surface-based measurements.
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