ArticleNature biotechnology2021
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation.
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Article in Nature biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 93 citations in OpenAlex.
- Muscle-Nerve Signaling and Neurogenic Inflammation in Temporomandibular Disorders: Potential Contributions of Occlusal Interference and Other Peripheral Triggers.Dentistry journal · 2026Review
- Towards a Whole-Body Assessment of Pain Using the 18 kDa Translocator Protein (TSPO) as a Broad-Spectrum Imaging Marker of Inflammation.European journal of pain (London, England) · 2026Review
- Neuro-Immune Axis in Trauma-Induced Heterotopic Ossification: Mechanisms and Therapeutic Implications.Cells · 2026Review
- Article
- The Neuroimmune Axis in Sepsis: From Pathophysiological Circuits to Precision Neuromodulation.Journal of inflammation research · 2026Review
- Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial-Neural Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multidimensional advances in neural interface technology for peripheral nerve repair: From material innovation to clinical translation.Materials today. Bio · 2025Review
- 3D-printed optogenetic neural probe integrated with microfluidic tube for opsin/drug delivery.Scientific reports · 2025Article
- Tumor-infiltrating nociceptor neurons promote immunosuppression.Science signaling · 2025Article
- Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants.Bioengineering & translational medicine · 2025Article
- Mechanism-based nonopioid analgesic targets.The Journal of clinical investigation · 2025Review
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- Staphylococcus Aureus Tames Nociceptive Neurons to Suppress Synovial Macrophage Responses for Sustained Infection in Septic Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Optogenetic activation of mechanical nociceptions to enhance implant osseointegration.Nature communications · 2025Article
- Failure behavior of polymer microelectrode arrays encapsulated with conventional ALD and 3D-ALI barriers.Frontiers in bioengineering and biotechnology · 2025Article
- Perspectives on non-genetic optoelectronic modulation biointerfaces for advancing healthcare.Med-X · 2024Article
- Setting the tone: nociceptors as conductors of immune responses.Trends in immunology · 2024Review
- Optogenetic Activation of Peripheral Somatosensory Neurons in Transgenic Mice as a Neuropathic Pain Model for Assessing the Therapeutic Efficacy of Analgesics.ACS pharmacology & translational science · 2024Article
- Alcohol use and the pain system.Advances in drug and alcohol research · 2024Review
- Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40).Bone research · 2023Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 4 countries.
Frédéric Michoud *Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.ORCID http://orcid.org/0000-0002-2930-1144
Corey Seehus *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Philipp Schönle *Integrated Systems Laboratory, Department of Information Technology and Electrical Engineering, Swiss Institute of Technology Zurich (ETHZ), Zurich, Switzerland.
Noé BrunIntegrated Systems Laboratory, Department of Information Technology and Electrical Engineering, Swiss Institute of Technology Zurich (ETHZ), Zurich, Switzerland.
Daniel TaubDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Zihe ZhangDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Aakanksha JainDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Ivan FurfaroLaboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Outman AkouissiLaboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Rachel MoonDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Pascale MeierIntegrated Systems Laboratory, Department of Information Technology and Electrical Engineering, Swiss Institute of Technology Zurich (ETHZ), Zurich, Switzerland.
Katia GalanLaboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Benjamin DoyleDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Michael TetreaultDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7273-671X
Sébastien TalbotDépartement de Pharmacologie et Physiologie, Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.
Liam E BrowneWolfson Institute for Biomedical Research, University College London, London, UK.ORCID http://orcid.org/0000-0002-5693-7703
Qiuting Huang *Integrated Systems Laboratory, Department of Information Technology and Electrical Engineering, Swiss Institute of Technology Zurich (ETHZ), Zurich, Switzerland. huang@iis.ee.ethz.ch.
Clifford J Woolf *Department of Neurobiology, Harvard Medical School, Boston, MA, USA. clifford.woolf@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-6636-3897
Stéphanie P Lacour *Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland. stephanie.lacour@epfl.ch.ORCID http://orcid.org/0000-0001-9075-4022
Boston Children's Hospital · USETH Zurich · CHWyss Center for Bio and Neuroengineering · CHUniversité de Montréal · CAWolfson Foundation · GB
Funding
Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5MNINDS NIH HHS R35 NS105076Wellcome TrustWellcome Trust 109372/Z/15/Z
Abstract
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation
Indexed as
OptogeneticsAnimalsBehavior, AnimalInflammationIntegrasesLightMiceMice, Inbred C57BLNeuronsNociceptorsTRPV Cation ChannelsCre recombinaseIntegrasesTRPV1 protein, mouseTRPV Cation Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.