Evidence map›Paper›PMID 32958937›Full record

ArticleNature metabolism2020

Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation.

Sander de Kivit, Mark Mensink, Anna T Hoekstra, Ilana Berlin, Rico J E Derks, Demi Both, Muhammad A Aslam, Derk Amsen, Celia R Berkers, Jannie Borst

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Lactic acid improves Treg manufacturing andMolecular therapy. Methods & clinical development · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Stable Isotope Tracing Experiments Using LC-MS.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  15. Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer.Journal of experimental & clinical cancer research : CR · 2024
    Review
  16. Article
  17. Review
  18. Review
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sander de Kivit *Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-0148-7802
Mark Mensink *Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-2470-6919
Anna T Hoekstra *Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, the Netherlands.
Ilana BerlinOncode Institute, Leiden University Medical Center, Leiden, the Netherlands.
Rico J E DerksCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-8920-7133
Demi BothDivision of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3850-9913
Muhammad A AslamDivision of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Derk AmsenDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Celia R BerkersBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, the Netherlands. c.r.berkers@uu.nl.ORCID http://orcid.org/0000-0003-0746-8565
Jannie BorstDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. j.g.borst@lumc.nl.ORCID http://orcid.org/0000-0002-8043-5009
Leiden University Medical Center · NLThe Netherlands Cancer Institute · NLSanquin · NLUniversity of Applied Sciences Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following activation, conventional T (T

Indexed as

CD3 ComplexCitric Acid CycleGlucoseGlycolysisHumansLactic AcidMetabolomePhosphatidylinositol 3-KinasesReceptors, Tumor Necrosis Factor, Type IIRNASequence Analysis, RNASignal TransductionT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesCD3 ComplexGlucoseLactic AcidPhosphatidylinositol 3-KinasesReceptors, Tumor Necrosis Factor, Type IIRNATNFRSF1B protein, humanTOR Serine-Threonine Kinases

Identifiers

PMID32958937
OpenAlexW3087749555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.