ArticleNature communications2020
Rational programming of history-dependent logic in cellular populations.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cascading recombinase memory switch for programmable and stable gene expression in Pseudomonas putida.Nucleic acids research · 2026Article
- Tunable low-rate genomic recombination with Cre-Applied and environmental microbiology · 2026Article
- A history-dependent integrase recorder of plant gene expression with single-cell resolution.Nature communications · 2024Article
- Engineering intelligent chassis cells via recombinase-based MEMORY circuits.Nature communications · 2024Article
- Customizing cellular signal processing by synthetic multi-level regulatory circuits.Nature communications · 2023Review
- Next generation synthetic memory via intercepting recombinase function.Nature communications · 2023Article
- An integrase toolbox to record gene-expression during plant development.Nature communications · 2023Article
- A DNA Finite-State Machine Based on the Programmable Allosteric Strategy of DNAzyme.International journal of molecular sciences · 2023Article
- Computational Methods for the Design of Recombinase Logic Circuits with Adaptable Circuit Specifications.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Synthetic memory circuits for stable cell reprogramming in plants.Nature biotechnology · 2022Article
- A localized DNA finite-state machine with temporal resolution.Science advances · 2022Article
- SYMBIOSIS: synthetic manipulable biobricks via orthogonal serine integrase systems.Nucleic acids research · 2022Article
- Future Challenges in Plant Systems Biology.Methods in molecular biology (Clifton, N.J.) · 2022Review
- A rapid and standardized workflow for functional assessment of bacterial biosensors in fecal samples.Frontiers in bioengineering and biotechnology · 2022Article
- Decoding and recoding plant development.Plant physiology · 2021Review
- Review
- Rational programming of history-dependent logic in cellular populations.Nature communications · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic programs operating in a history-dependent fashion are ubiquitous in nature and govern sophisticated processes such as development and differentiation. The ability to systematically and predictably encode such programs would advance the engineering of synthetic organisms and ecosystems with rich signal processing abilities. Here we implement robust, scalable history-dependent programs by distributing the computational labor across a cellular population. Our design is based on standardized recombinase-driven DNA scaffolds expressing different genes according to the order of occurrence of inputs. These multicellular computing systems are highly modular, do not require cell-cell communication channels, and any program can be built by differential composition of strains containing well-characterized logic scaffolds. We developed automated workflows that researchers can use to streamline program design and optimization. We anticipate that the history-dependent programs presented here will support many applications using cellular populations for material engineering, biomanufacturing and healthcare.
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