ArticleNature communications2020
Ring-opening functionalizations of unstrained cyclic amines enabled by difluorocarbene transfer.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A difluorocarbene-triggered annulation/ring expansion cascadeChemical science · 2026Article
- Ring-Opening Chlorination and Bromination of Pyrazolopyridines and Isoxazoles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Site-Selective Carbonylation of Azetidines via Copper-Catalyzed Difluorocarbene Insertion.Angewandte Chemie (International ed. in English) · 2025Article
- Catalytic difluorocarbene insertion enables access to fluorinated oxetane isosteres.Nature chemistry · 2025Article
- Selective C-N Bond Cleavage in Unstrained Pyrrolidines Enabled by Lewis Acid and Photoredox Catalysis.Journal of the American Chemical Society · 2024Article
- Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents.Organic & biomolecular chemistry · 2024Article
- Palladium-catalyzed difluorocarbene transfer enables access to enantioenriched chiral spirooxindoles.Nature communications · 2024Article
- Electrochemical synthesis of peptide aldehydes via C‒N bond cleavage of cyclic amines.Nature communications · 2024Article
- Difluorocarbene-induced [1,2]- and [2,3]-Stevens rearrangement of tertiary amines.Nature communications · 2024Article
- Short, Scalable Access to Pyrrovobasine.JACS Au · 2023Article
- Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery.SynOpen (2017) · 2023Article
- Palladium-Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes.Angewandte Chemie (International ed. in English) · 2022Article
- Synthesis of Polycyclic Isoindolines via α-C-H/N-H Annulation of Alicyclic Amines.Organic letters · 2022Article
- Surprising Condensation Reactions of the Azadithiolate Cofactor.Angewandte Chemie (International ed. in English) · 2021Article
- α,α'-C-H Bond Difunctionalization of Unprotected Alicyclic Amines.Organic letters · 2021Article
- Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines.Nature communications · 2021Article
- C-H Bond Functionalization of Amines: A Graphical Overview of Diverse Methods.SynOpen (2017) · 2021Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical synthesis based on the skeletal variation has been prolifically utilized as an attractive approach for modification of molecular properties. Given the ubiquity of unstrained cyclic amines, the ability to directly alter such motifs would grant an efficient platform to access unique chemical space. Here, we report a highly efficient and practical strategy that enables the selective ring-opening functionalization of unstrained cyclic amines. The use of difluorocarbene leads to a wide variety of multifaceted acyclic architectures, which can be further diversified to a range of distinctive homologative cyclic scaffolds. The virtue of this deconstructive strategy is demonstrated by successful modification of several natural products and pharmaceutical analogues.
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