ArticleTranslational psychiatry2020
The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Are behavioural and inflammatory profiles different according to type of stressor, developmental stage, and sex in rodent models of depression? A systematic review.Molecular psychiatry · 2025Pooled it
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Nonlinear association between body mass index, perceived discrimination, and psychological sub-health problems among adolescents: risks of undernutrition versus overnutrition.BMC psychology · 2026Article
- Effects of Clicker Training on Behavioral and Stress Markers of Welfare in the F1 Generation of CD1 Mice: A Pilot Study.Animals : an open access journal from MDPI · 2026Article
- Outbred mice as an appropriate model for evaluating the immunogenicity of vaccines against porcine circovirus 2.Open veterinary journal · 2026Article
- Behavioral impact of adolescent social isolation stress: A multidimensional assessment in male NMRI mice.Learning & behavior · 2026Article
- Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice.GeroScience · 2026Article
- Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration.bioRxiv : the preprint server for biology · 2026Article
- Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response.Biology of sex differences · 2026Article
- High-yield induced ovulation in the adult marsupial fat-tailed dunnart (Sminthopsis crassicaudata).Scientific reports · 2026Article
- Antioxidant and neuromodulatory effect of gallic acid prevents anxiety-like symptoms of omeprazole.RSC advances · 2026Article
- A Low-Stress, Long-Duration Stable Tail Vein Catheterization and Precise Drug Delivery Protocol for Awake, Freely Moving Mice.Bio-protocol · 2026Article
- Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration.Frontiers in neuroscience · 2026Article
- Social isolation, loneliness, genetic susceptibility, and the hazard of incident osteoporosis.International journal of surgery (London, England) · 2026Article
- Prolonged Aggressive Experience Accelerates Resolution of Inflammation in Blood and Microglia After Repeated LPS Treatment.International journal of molecular sciences · 2025Article
- Comparative Evaluation of Analgesics in a Murine Bile Duct Ligation Model.Biomedicines · 2025Article
- Social Housing of Male CD-1 Mice (Mus musculus) in the Toxicological Setting: A 28-Day Social Compatibility Study of Male Mice following Oral Gavage of Theophylline.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit.Molecular psychiatry · 2025Article
- The mouse gut microbiota responds to predator odor and predicts host behavior.bioRxiv : the preprint server for biology · 2025Article
- Prefrontal cortical microglial transcriptome relates to mouse offspring executive function deficits after perinatal opioid exposure in a sex-dependent manner.Brain, behavior, and immunity · 2025Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Chronic stress can alter the immune system, adult hippocampal neurogenesis and induce anxiety- and depressive-like behaviour in rodents. However, previous studies have not discriminated between the effect(s) of different types of stress on these behavioural and biological outcomes. We investigated the effect(s) of repeated injection vs. permanent social isolation on behaviour, stress responsivity, immune system functioning and hippocampal neurogenesis, in young adult male mice, and found that the type of stress exposure does indeed matter. Exposure to 6 weeks of repeated injection resulted in an anxiety-like phenotype, decreased systemic inflammation (i.e., reduced plasma levels of TNFα and IL4), increased corticosterone reactivity, increased microglial activation and decreased neuronal differentiation in the dentate gyrus (DG). In contrast, exposure to 6 weeks of permanent social isolation resulted in a depressive-like phenotype, increased plasma levels of TNFα, decreased plasma levels of IL10 and VEGF, decreased corticosterone reactivity, decreased microglial cell density and increased cell density for radial glia, s100β-positive cells and mature neuroblasts-all in the DG. Interestingly, combining the two distinct stress paradigms did not have an additive effect on behavioural and biological outcomes, but resulted in yet a different phenotype, characterized by increased anxiety-like behaviour, decreased plasma levels of IL1β, IL4 and VEGF, and decreased hippocampal neuronal differentiation, without altered neuroinflammation or corticosterone reactivity. These findings demonstrate that different forms of chronic stress can differentially alter both behavioural and biological outcomes in young adult male mice, and that combining multiple stressors may not necessarily cause more severe pathological outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.