Evidence map›Paper›PMID 32958712›Full record

ArticleAntimicrobial agents and chemotherapy2020

A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'-

Ratna Karuna, Fumiaki Yokokawa, Keshi Wang, Jin Zhang, Haoying Xu, Gang Wang, Mei Ding, Wai Ling Chan, Nahdiyah Abdul Ghafar, Andrea Leonardi and 14 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 3 countries.

Ratna KarunaNovartis Institute for Tropical Diseases, Singapore.ORCID 0000-0003-0508-2490
Fumiaki YokokawaNovartis Institute for Tropical Diseases, Singapore.
Keshi WangNovartis Institutes for BioMedical Research, Emeryville, California, USA.
Jin ZhangNovartis Institutes for BioMedical Research, East Hanover, New Jersey, USA.
Haoying XuNovartis Institute for Tropical Diseases, Singapore.
Gang WangNovartis Institute for Tropical Diseases, Singapore.
Mei DingNovartis Institute for Tropical Diseases, Singapore.
Wai Ling ChanNovartis Institute for Tropical Diseases, Singapore.
Nahdiyah Abdul GhafarNovartis Institute for Tropical Diseases, Singapore.
Andrea LeonardiNovartis Institute for Tropical Diseases, Singapore.
Cheah Chen SehNovartis Institute for Tropical Diseases, Singapore.
Peck Gee SeahNovartis Institute for Tropical Diseases, Singapore.
Wei LiuNovartis Institute for Tropical Diseases, Singapore.
Rao P S SrinivasaNovartis Institute for Tropical Diseases, Singapore.
Siew Pheng LimNovartis Institute for Tropical Diseases, Singapore.ORCID 0000-0002-7377-5662
Suresh B LakshminarayanaNovartis Institute for Tropical Diseases, Singapore.
Ellie GrowcottNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Sreehari BabuNovartis Global Drug Development, Shanghai, China.
Martijn FenauxNovartis Institutes for BioMedical Research, Emeryville, California, USA.
Weidong ZhongNovartis Institutes for BioMedical Research, Emeryville, California, USA.
Feng GuNovartis Institute for Tropical Diseases, Singapore.
Pei-Yong ShiNovartis Institute for Tropical Diseases, Singapore.
Francesca BlascoNovartis Institute for Tropical Diseases, Singapore.
Yen-Liang ChenNovartis Institute for Tropical Diseases, Singapore yen_liang.chen@novartis.com.ORCID 0000-0002-0121-5658
Novartis (Singapore) · SGNovartis (United States) · USNovartis (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monophosphate prodrug analogs of 2'-deoxy-2'-fluoro-2'-

Indexed as

DengueProdrugsAmidesAnimalsAntiviral AgentsDogsFemaleGuanosineHepacivirusLeukocytes, MononuclearMalePhosphoric Acids8-methylguanosineAmidesAntiviral AgentsGuanosinephosphoramidic acidPhosphoric AcidsProdrugscyclic phosphoramidatedenguemonophosphate prodrugnucleoside triphosphatenucleotide analogpolymerase inhibitor

Identifiers

PMID32958712
PMCPMC7674056
OpenAlexW3087721845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.