Evidence map›Paper›PMID 32958661›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.

Gonzalo Fernandez Lahore, Bruno Raposo, Marie Lagerquist, Claes Ohlsson, Pierre Sabatier, Bingze Xu, Mike Aoun, Jaime James, Xiaojie Cai, Roman A Zubarev and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Observational
  10. Review
  11. Review
  12. Review
  13. Review
  14. Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Gonzalo Fernandez LahoreDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden; gonzalo.fernandez.lahore@ki.se ikard.holmdahl@ki.se.ORCID 0000-0002-4291-0251
Bruno RaposoDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.ORCID 0000-0003-3918-4882
Marie LagerquistCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.ORCID 0000-0002-9089-8605
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.ORCID 0000-0002-9633-2805
Pierre SabatierDivision of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.ORCID 0000-0002-2734-1791
Bingze XuDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.ORCID 0000-0002-5341-1722
Mike AounDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
Jaime JamesDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.
Xiaojie CaiDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.ORCID 0000-0001-8103-6934
Roman A ZubarevDepartment of Pharmacological & Technological Chemistry, I. M. Sechenov First Moscow State Medical University, 119146 Moscow, Russia.ORCID 0000-0001-9839-2089
Kutty Selva NandakumarDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden.ORCID 0000-0001-7790-8197
Rikard HolmdahlDivision of Medical Inflammation Research, Department Of Medical Biochemistry and Biophysics, Karolinska Institute, 17176 Stockholm, Sweden; gonzalo.fernandez.lahore@ki.se ikard.holmdahl@ki.se.ORCID 0000-0002-4969-2576
Karolinska Institutet · SEUniversity of Gothenburg · SESechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has proven difficult to identify the underlying genes in complex autoimmune diseases. Here, we use forward genetics to identify polymorphisms in the vitamin D receptor gene (

Indexed as

AnimalsGene Expression RegulationHumansInflammationMicePolymorphism, GeneticReceptors, CalcitriolT-LymphocytesVitamin DVitamin D DeficiencyReceptors, CalcitriolVDR protein, humanVitamin DgeneticsinflammationT cellsvitamin Dvitamin D receptor

Identifiers

PMID32958661
PMCPMC7547217
OpenAlexW3087454025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.