Evidence map›Paper›PMID 32958658›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Variants in

Sydney R Abrams, Alexandra L Hawks, Jacquelyn M Evans, Thomas R Famula, Mary Mahaffey, Gary S Johnson, Jennifer M Mason, Leigh Anne Clark

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Genomic analyses identify 15 risk loci and revealProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. GWAS using low-pass whole genome sequence reveals a novel locus in canine congenital idiopathic megaesophagus.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Sydney R AbramsDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634.ORCID 0000-0001-9958-1324
Alexandra L HawksDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634.ORCID 0000-0003-0480-7082
Jacquelyn M EvansDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634.ORCID 0000-0003-1272-0059
Thomas R FamulaDepartment of Animal Science, University of California, Davis, CA 95616.ORCID 0000-0002-3139-9849
Mary MahaffeyDepartment of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0002-5886-0156
Gary S JohnsonDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211.
Jennifer M MasonDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634.
Leigh Anne ClarkDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC 29634; lclark4@clemson.edu.
Clemson University · USMissouri College · USNational Human Genome Research Institute · USUniversity of California, Davis · USUniversity of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Domesticated dogs show unparalleled diversity in body size across breeds, but within breeds variation is limited by selective breeding. Many heritable diseases of dogs are found among breeds of similar sizes, suggesting that as in humans, alleles governing growth have pleiotropic effects. Here, we conducted independent genome-wide association studies in the small Shetland Sheepdog breed and discovered a locus on chromosome 9 that is associated with a dental abnormality called maxillary canine-tooth mesioversion (MCM) (

Indexed as

Genome-Wide Association StudyAllelesAnimalsBody SizeBody WeightBreedingDogsExonsGenotypeGrowth HormoneHaplotypesMethyltransferasesPolymorphism, Single NucleotideGrowth HormoneMethyltransferasesRNA 2'-O-methyltransferaseFTSJ3GH1heightIGF1weight

Identifiers

PMID32958658
PMCPMC7547249
OpenAlexW3087121755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.