Evidence map›Paper›PMID 32958655›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Ultrasensitive CRISPR-based diagnostic for field-applicable detection of

Rose A Lee, Helena De Puig, Peter Q Nguyen, Nicolaas M Angenent-Mari, Nina M Donghia, James P McGee, Jeffrey D Dvorin, Catherine M Klapperich, Nira R Pollock, James J Collins

Open access · hybridAbstract readEvaluation Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
26.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 239 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Towards deployable CRISPR-based nucleic acid detection.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  5. Article
  6. Review
  7. Article
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  14. Article
  15. The role of autophagy in protozoan infections.Frontiers in cellular and infection microbiology · 2026
    Review
  16. Article
  17. AsCas12a tolerates insertions in target DNA.Nucleic acids research · 2025
    Article
  18. Review
  19. Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Rose A LeeWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115.
Helena De PuigWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115.
Peter Q NguyenWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115.
Nicolaas M Angenent-MariWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115.
Nina M DonghiaWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115.
James P McGeeDivision of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0003-0225-1172
Jeffrey D DvorinDivision of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-5883-7271
Catherine M KlapperichDepartment of Biomedical Engineering, Boston University, Boston, MA 02215.ORCID 0000-0001-6103-849X
Nira R PollockDivision of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
James J CollinsWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; jimjc@mit.edu.ORCID 0000-0002-5560-8246
Boston Children's Hospital · USHarvard University · USBoston University · USBroad Institute · US

Funding

Molecular mechanisms of schizogony in malaria parasitesR01AI145941 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DVORIN, JEFFREY D · 2019 to 2023
$3.1M
NIAID NIH HHS R01 AI145941
6 · The paper itself

Abstract

Asymptomatic carriers of

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsDiagnostic Techniques and ProceduresGenetic TechniquesCarrier StateHumansMalariaPlasmodiumCRISPR-DxdiagnosticsmalariaSHERLOCK

Identifiers

PMID32958655
PMCPMC7568265
OpenAlexW3087209706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.