Evidence map›Paper›PMID 32958651›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Melatonin promotes sleep by activating the BK channel in

Longgang Niu, Yan Li, Pengyu Zong, Ping Liu, Yuan Shui, Bojun Chen, Zhao-Wen Wang

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Efficacy ofFrontiers in neurology · 2022
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Circadian Control of Sleep by Melatonin via MTbioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Regulation of Neurotransmitter Release by KAdvances in neurobiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Longgang NiuDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030-3401.
Yan LiDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030-3401.
Pengyu ZongDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030-3401.
Ping LiuDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030-3401.ORCID 0000-0003-4909-4282
Yuan ShuiDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030-3401.ORCID 0000-0001-5874-5812
Bojun ChenDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030-3401 bochen@uchc.edu zwwang@uchc.edu.ORCID 0000-0002-1141-9101
Zhao-Wen WangDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030-3401 bochen@uchc.edu zwwang@uchc.edu.

Funding

Synaptic function of BK channel-interacting proteinsR01MH085927 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZHAO-WEN WANG · 2010 to 2026
$6.7M
The function of gap junctions and chemical synapses in a simple neural circuitR01NS109388 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WANG, ZHAO-WEN · 2018 to 2022
$2.0M
Novel proteins regulating function and expression of SLO-2 potassium channelsR01GM113004 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CHEN, BOJUN · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM113004NIMH NIH HHS R01 MH085927NINDS NIH HHS R01 NS109388
6 · The paper itself

Abstract

Melatonin (Mel) promotes sleep through G protein-coupled receptors. However, the downstream molecular target(s) is unknown. We identified the

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Knockout TechniquesHumansLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMelatoninNeuronsReceptor, Melatonin, MT2SleepSynaptic TransmissionCaenorhabditis elegans ProteinsKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMelatoninReceptor, Melatonin, MT2slo-1 protein, C elegansBK channelmelatoninmelatonin receptorPCDR-1sleep

Identifiers

PMID32958651
PMCPMC7547285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.