ArticleProceedings of the National Academy of Sciences of the United States of America2020
Circulating testican-2 is a podocyte-derived marker of kidney health.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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18 citing papers in PubMed, 35 citations in OpenAlex.
- Testican-2 (SPOCK2): A multifunctional matricellular regulator.Matrix biology : journal of the International Society for Matrix Biology · 2026Review
- Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.medRxiv : the preprint server for health sciences · 2026Article
- Circulating Testican-2 and MGT5A are Markers of Membranous Nephropathy.Kidney international reports · 2026Article
- Joslin Kidney Panel of Circulating Proteins: A Tool for ESKD Risk Discrimination and Individualized Diabetic Kidney Disease Treatment.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Renal Arteriovenous Gradients for Greater Than 10,000 Circulating Proteins.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Article
- Plasma Proteomics of Diabetic Kidney Disease Among Asians With Younger-Onset Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- Proteomics and Incident Kidney Failure in Individuals With CKD: The African American Study of Kidney Disease and Hypertension and the Boston Kidney Biopsy Cohort.Kidney medicine · 2024Article
- Circulating proteins linked to apoptosis processes and fast development of end-stage kidney disease in diabetes.JCI insight · 2024Article
- Small RNA sequencing reveals snoRNAs and piRNA-019825 as novel players in diabetic kidney disease.Endocrine · 2024Article
- Proteomics: Progress and Promise of High-Throughput Proteomics in Chronic Kidney Disease.Molecular & cellular proteomics : MCP · 2023Article
- Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice.Acta pharmacologica Sinica · 2022Article
- Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.Kidney international · 2022Article
- Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods.Science advances · 2022Article
- Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes.Kidney international · 2022Article
- suPAR: An Inflammatory Mediator for Kidneys.Kidney diseases (Basel, Switzerland) · 2022Review
- Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing.European journal of epidemiology · 2022Article
- Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.American journal of human genetics · 2021Article
- Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease.Frontiers in medicine · 2021Review
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Authors and funding
25 authors at 9 institutions in 2 countries.
Debby NgoDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.ORCID 0000-0003-2681-3475
Donghai WenNephrology Division, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0003-2707-036X
Yan GaoJackson Heart Study, Department of Medicine, University of Mississippi, Jackson, MS 39216.
Michelle J KeyesDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Erika R DruryDivision of Nephrology, University of Rochester School of Medicine, Rochester, NY 14642.
Dan H KatzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.ORCID 0000-0001-7237-8502
Mark D BensonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.ORCID 0000-0001-8977-2389
Sumita SinhaDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Dongxiao ShenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Laurie A FarrellDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.ORCID 0000-0002-5717-527X
Bennet D PetersonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
David J FriedmanDivision of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Sammy ElmariahCardiology Division, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-8013-8733
Bessie A YoungKidney Research Institute, University of Washington, Seattle, WA 98104.
J Gustav SmithDepartment of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, 221 84 Lund, Sweden.ORCID 0000-0001-6285-9935
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118.ORCID 0000-0002-3658-1375
Ramachandran S VasanDivision of Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118.ORCID 0000-0001-7357-5970
Martin G LarsonDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118.ORCID 0000-0002-9631-1254
Adolfo CorreaJackson Heart Study, Department of Medicine, University of Mississippi, Jackson, MS 39216.
Benjamin D HumphreysDivision of Nephrology, Washington University of St. Louis School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-6420-8703
Thomas J WangDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-4063-6508
Martin R PollakDivision of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215; mpollak@bidmc.harvard.edu eprhee@partners.org.
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.ORCID 0000-0002-6767-7687
Eugene P RheeNephrology Division, Massachusetts General Hospital, Boston, MA 02114; mpollak@bidmc.harvard.edu eprhee@partners.org.ORCID 0000-0002-4804-7583
Beth Israel Deaconess Medical Center · USBoston University · USMassachusetts General Hospital · USJackson Memorial Hospital · USLund University · SEThe University of Texas Southwestern Medical Center · USUniversity of Rochester · USUniversity of Washington · USWashington University in St. Louis · US
Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MTRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGYT32DK007540 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS, SOBERMAN, ROY · 1986 to 2021
$7.2MProteomics of Cardiometabolic and Renal Traits in African AmericansR01HL133870 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROBERT E GERSZTEN · 2017 to 2026
$6.7MProteomic Pathway Discovery in Cardiovascular DiseaseR01HL132320 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GERSZTEN, ROBERT E, RAMACHANDRAN, VASAN S · 2016 to 2019
$3.4MMetabolomics of Uremic Symptoms in Dialysis PatientsR01NR017399 · NINR · MASSACHUSETTS GENERAL HOSPITAL · PI RHEE, EUGENE P., SHAFI, TARIQ · 2018 to 2023
$2.8MMetabolomics of CKD and CKD ProgressionU01DK106981 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RHEE, EUGENE P. · 2015 to 2019
$2.2MThe Role of PPM1G in Apolipoprotein E Biology and Atherosclerotic Cardiovascular DiseaseK08HL145095 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BENSON, MARK DANIEL · 2019 to 2023
$836kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K08 HL145095NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL132320NHLBI NIH HHS R01 HL133870NIDDK NIH HHS T32 DK007540NIDDK NIH HHS U01 DK106981NIMHD NIH HHS HHSN268201800013ININR NIH HHS R01 NR017399
Abstract
In addition to their fundamental role in clearance, the kidneys release select molecules into the circulation, but whether any of these anabolic functions provides insight on kidney health is unknown. Using aptamer-based proteomics, we characterized arterial (A)-to-renal venous (V) gradients for >1,300 proteins in 22 individuals who underwent invasive sampling. Although most of the proteins that changed significantly decreased from A to V, consistent with renal clearance, several were found to increase, the most significant of which was testican-2. To assess the clinical implications of these physiologic findings, we examined proteomic data in the Jackson Heart Study (JHS), an African-American cohort (
Indexed as
ProteomicsAptamers, PeptideBiomarkersBlack or African AmericanFemaleGlomerular Filtration RateHumansHypertensionKidneyKidney Function TestsKidney GlomerulusMaleMiddle AgedPodocytesProteoglycansAptamers, PeptideBiomarkersProteoglycansSPOCK2 protein, humanchronic kidney diseaseproteomicstestican-2
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