ArticleProceedings of the National Academy of Sciences of the United States of America2020
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
36 citing papers in PubMed, 65 citations in OpenAlex.
- The MHC-I related protein 1 MR1 can bind host purine catabolites.The Journal of biological chemistry · 2026Article
- Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition.Immunology and cell biology · 2026Article
- Allelic variation alters expression and antigen presentation of MR1 allomorphs.The Journal of biological chemistry · 2026Article
- Sorting endosomes play key roles in presentation of Mycobacterium tuberculosis-derived ligands to MAIT cells.Scientific reports · 2026Article
- A miniaturized MR1 metabolite display system with native-like protein features.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens.The Journal of biological chemistry · 2026Article
- The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites.The Journal of experimental medicine · 2026Article
- Review
- Sorting endosomes play key roles in presentation ofbioRxiv : the preprint server for biology · 2025Article
- Acetoacetate suppresses colon cancer via an MR1-MAIT axis.bioRxiv : the preprint server for biology · 2025Article
- Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection.PLoS pathogens · 2025Article
- Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions.Immunological reviews · 2025Review
- CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development.Frontiers in immunology · 2025Review
- Impaired endocytosis and accumulation in early endosomal compartments defines herpes simplex virus-mediated disruption of the nonclassical MHC class I-related molecule MR1.The Journal of biological chemistry · 2024Article
- MR1 antigen presentation to MAIT cells and other MR1-restricted T cells.Nature reviews. Immunology · 2024Review
- Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.Communications biology · 2024Article
- Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection.iScience · 2024Article
- Sulfated bile acid is a host-derived ligand for MAIT cells.Science immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 2 countries.
Hamish E G McWilliamDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; hamish.mcwilliam@unimelb.edu.au d.fairlie@imb.uq.edu.au j.villadangos@unimelb.edu.au.ORCID 0000-0003-3479-3419
Jeffrey Y W MakDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-8011-4539
Wael AwadInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-7597-2133
Matthew ZorkauDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Sebastian Cruz-GomezDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Hui Jing LimDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Yuting YanDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0001-7081-2037
Sam WormaldDivision of Systems Biology and Personalised Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Laura F DagleyDivision of Systems Biology and Personalised Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.ORCID 0000-0003-4171-3712
Sidonia B G EckleDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0003-0766-171X
Alexandra J CorbettDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0003-1618-4337
Haiyin LiuDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, VIC 3010, Australia.ORCID 0000-0003-3103-6949
Shihan LiDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Scott J J ReddiexDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-1047-5718
Justine D MinternDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, VIC 3010, Australia.ORCID 0000-0002-3797-8577
Ligong LiuDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-2693-1896
James McCluskeyDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-8597-815X
Jamie RossjohnInfection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-2020-7522
David P FairlieDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia; hamish.mcwilliam@unimelb.edu.au d.fairlie@imb.uq.edu.au j.villadangos@unimelb.edu.au.ORCID 0000-0002-7856-8566
Jose A VilladangosDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; hamish.mcwilliam@unimelb.edu.au d.fairlie@imb.uq.edu.au j.villadangos@unimelb.edu.au.ORCID 0000-0001-6771-8891
The University of Melbourne · AUAustralian Research Council · AURoyal Children's Hospital · AU
Funding
Investigating the basis of MAIT cell antigen potencyR01AI148407 · NIAID · UNIVERSITY OF MELBOURNE · PI MCCLUSKEY, JAMES · 2020 to 2024
$2.7MNIAID NIH HHS R01 AI148407
Abstract
The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B
Indexed as
ProteomicsAntigen PresentationAntigensCRISPR-Cas SystemsEndoplasmic ReticulumHistocompatibility Antigens Class IHumansLigandsLymphocyte ActivationMembrane Transport ProteinsMetabolomeMinor Histocompatibility AntigensMolecular ChaperonesMucosal-Associated Invariant T CellsRiboflavinAntigensHistocompatibility Antigens Class ILigandsMembrane Transport ProteinsMinor Histocompatibility AntigensMolecular ChaperonesMR1 protein, humanRiboflavintapasinfluorescent probeMAIT cellsMHC class I-related protein 1 (MR1)protein traffickingvitamin B
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.