Evidence map›Paper›PMID 32958429›Full record

ArticleAcademic radiology2021

Atherosclerotic Plaque Burden on Abdominal CT: Automated Assessment With Deep Learning on Noncontrast and Contrast-enhanced Scans.

Ronald M Summers, Daniel C Elton, Sungwon Lee, Yingying Zhu, Jiamin Liu, Mohammedhadi Bagheri, Veit Sandfort, Peter C Grayson, Nehal N Mehta, Peter A Pinto and 5 more

Open access · greenAbstract read
In one paragraph

Article in Academic radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

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  6. Tumor-Derived Polyamines Initiate Fat Wasting in Cancer Cachexia.bioRxiv : the preprint server for biology · 2025
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  19. Opportunistic Screening:Radiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Ronald M SummersRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg. 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182. Electronic address: rms@nih.gov.
Daniel C EltonRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg. 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182.
Sungwon LeeRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg. 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182.
Yingying ZhuRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg. 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182.
Jiamin LiuRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg. 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182.
Mohammedhadi BagheriRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg. 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182.
Veit SandfortRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg. 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182.
Peter C GraysonNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Peter A PintoUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
W Marston LinehanUrologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Alberto A PerezDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Peter M GraffyDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Stacy D O'ConnorDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Perry J PickhardtDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
National Institutes of Health Clinical Center · USUniversity of Wisconsin–Madison · USNational Institutes of Health · USCenter for Cancer Research · USNational Heart Lung and Blood Institute · US

Funding

Vasculitis and Translational MedicineZIAAR041204 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GRAYSON, PETER · 2015 to 2025
$15.4M
Prostate SectionZIABC011081 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PINTO, PETER · 2009 to 2025
$15.2M
Computer Aided Detection for CT ColonographyZ01CL040003 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2003 to 2008
$368k
Computer Aided Detection for Radiologic ImagesZ01CL040004 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2003 to 2008
$41k
Computer Aided Detection for CT ColonographyZIACL040003 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
Computer Aided Detection for Radiologic ImagesZIACL040004 · CLC · CLINICAL CENTER · PI SUMMERS, RONALD M. · 2009 to 2025
$0k
Intramural NIH HHS Z01 CL040003Intramural NIH HHS Z01 CL040004
6 · The paper itself

Abstract

backgroundAbdominal aortic atherosclerotic plaque burden may have clinical significance but manual measurement is time-consuming and impractical. PURPOSE: To perform external validation on an automated atherosclerotic plaque detector for noncontrast and postcontrast abdominal CT. MATERIALS AND

methodsThe training data consisted of 114 noncontrast CT scans and 23 postcontrast CT urography scans. The testing data set consisted of 922 CT colonography (CTC) scans, and 1207 paired noncontrast and postcontrast CT scans from renal donors from a second institution. Reference standard data included manual plaque segmentations in the 137 training scans and manual plaque burden measurements in the 922 CTC scans. The total Agatston score and group (0-3) was determined using fully-automated deep learning software. Performance was assessed by measures of agreement, linear regression, and paired evaluations.

resultsOn CTC scans, automated Agatston scoring correlated highly with manual assessment (R

conclusionFully automated detection, segmentation, and scoring of abdominal aortic atherosclerotic plaques on both pre- and post-contrast CT was validated and may have application for population-based studies.

Indexed as

Deep LearningPlaque, AtheroscleroticAbdomenAorta, AbdominalHumansTomography, X-Ray Computed3D-UNetAgatston scoreImage processingmachine learning

Identifiers

PMID32958429
PMCPMC7969468
OpenAlexW3087362837

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.