Evidence map›Paper›PMID 32957983›Full record

Observational studyRespiratory research2020

Patterns of adaptive servo-ventilation settings in a real-life multicenter study: pay attention to volume! : Adaptive servo-ventilation settings in real-life conditions.

Dany Jaffuel, Claudio Rabec, Carole Philippe, Jean-Pierre Mallet, Marjolaine Georges, Stefania Redolfi, Alain Palot, Carey M Suehs, Erika Nogue, Nicolas Molinari and 1 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02429986 (Observational and Transversal Study of Patients Treated in "Real Life"Conditions With Adaptive Servo-Ventilation), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02429986 nacompletednot on this map

Observational and Transversal Study of Patients Treated in "Real Life"Conditions With Adaptive Servo-Ventilation

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2015 to 2017Enrolled214ConditionsChronic Heart Failure and, Complex Sleep Apnea Syndrome, Obstructive Sleep Apnea Syndrome and, Idiopathic Central Sleep Apnea SyndromeArmsAdaptive Servo-Ventilation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. [Sleep Innovation].Open respiratory archives · 2024
    Review
  3. APAP, BPAP, CPAP, and New Modes of Positive Airway Pressure Therapy.Advances in experimental medicine and biology · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Dany JaffuelDepartment of Respiratory Diseases, Univ Montpellier, CHU Montpellier, 371, Avenue Doyen Giraud, 34295, Montpellier Cedex 5, France. dany.jaffuel@wanadoo.fr.ORCID http://orcid.org/0000-0002-6964-4766
Claudio RabecPulmonary Department and Respiratory Critical Care Unit, University Hospital Dijon, Dijon, France.
Carole PhilippeCentre des pathologies du sommeil, Hôpital Universitaire de la Pitié Salpêtrière, AP-HP, Paris, France.
Jean-Pierre MalletDepartment of Respiratory Diseases, Univ Montpellier, CHU Montpellier, 371, Avenue Doyen Giraud, 34295, Montpellier Cedex 5, France.
Marjolaine GeorgesCentre des pathologies du sommeil, Hôpital Universitaire de la Pitié Salpêtrière, AP-HP, Paris, France.
Stefania RedolfiPulmonary Department and Respiratory Critical Care Unit, University Hospital Dijon, Dijon, France.
Alain PalotClinique des Bronches, Allergies et du Sommeil, Assistance Publique Hôpitaux de Marseille, France et INSERM U1067, CNRS UMR 7333 Aix Marseille Université, 13015, Marseille, France, Hôpital Saint-Joseph, 26, boulevard de Louvain, 13285, Marseille, France.
Carey M SuehsDepartment of Respiratory Diseases, Univ Montpellier, CHU Montpellier, 371, Avenue Doyen Giraud, 34295, Montpellier Cedex 5, France.
Erika NogueClinical Research and Epidemiology Unit (URCE), Univ Montpellier, CHU Montpellier, Montpellier, France.
Nicolas MolinariDepartment of Medical Information, Univ Montpellier, CHU Montpellier, Montpellier, France.
Arnaud BourdinDepartment of Respiratory Diseases, Univ Montpellier, CHU Montpellier, 371, Avenue Doyen Giraud, 34295, Montpellier Cedex 5, France.
Centre National de la Recherche Scientifique · FRMaison des Sciences sociales et des Humanités de Dijon · FRSorbonne Université · FRUniversité de Montpellier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsTo explain the excess cardiovascular mortality observed in the SERVE-HF study, it was hypothesized that the high-pressure ASV default settings used lead to inappropriate ventilation, cascading negative consequences (i.e. not only pro-arrythmogenic effects through metabolic/electrolyte abnormalities, but also lower cardiac output). The aims of this study are: i) to describe ASV-settings for long-term ASV-populations in real-life conditions; ii) to describe the associated minute-ventilations (MV) and therapeutic pressures for servo-controlled-flow versus servo-controlled-volume devices (ASV-F Philips®-devices versus ASV-V ResMed®-devices).

methodsThe OTRLASV-study is a cross-sectional, 5-centre study including patients who underwent ASV-treatment for at least 1 year. The eight participating clinicians were free to adjust ASV settings, which were compared among i) initial diagnosed sleep-disordered-breathing (SBD) groups (Obstructive-Sleep-Apnea (OSA), Central-Sleep-Apnea (CSA), Treatment-Emergent-Central-Sleep-Apnea (TECSA)), and ii) unsupervised groups (k-means clusters). To generate these clusters, baseline and follow-up variables were used (age, sex, body mass index (BMI), initial diagnosed Obstructive-Apnea-Index, initial diagnosed Central-Apnea-Index, Continuous-Positive-Airway-Pressure used before ASV treatment, presence of cardiopathy, and presence of a reduced left-ventricular-ejection-fraction (LVEF)). ASV-data were collected using the manufacturer's software for 6 months.

resultsOne hundred seventy-seven patients (87.57% male) were analysed with a median (IQ

conclusionsReal-life ASV settings are associated with combinations of baseline and follow-up variables wherein cardiological variables remain clinically meaningful. At the patient level, a hyperventilation risk exists regardless of cluster or ASV-monitoring type, spotlighting a future role of MV-telemonitoring in the interest of patient-safety.

trial registrationThe OTRLASV study was registered on ClinicalTrials.gov (Identifier: NCT02429986 ). 1 April 2015.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveTidal VolumeAgedCross-Sectional StudiesFemaleFollow-Up StudiesHumansMalePulmonary VentilationRespiration, ArtificialSleep Apnea SyndromesAdaptive servo-ventilationCardiopathyClusterMinute volumePressureSettingSleep-disordered breathingTidal volume

Identifiers

PMID32957983
PMCPMC7507637
OpenAlexW3087001289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.